Introduction There is a growing body of evidence that subtle deficits in instrumental activities
of daily living (IADL) may be present in mild cognitive impairment (MCI). However, it is not …

Vascular cognitive impairment (VCI) was proposed as an umbrella term to include subjects
affected with any degree of cognitive impairment resulting from cerebrovascular disease (…

Criteria for the diagnosis of vascular dementia (VaD) that are reliable, valid, and readily
applicable in a variety of settings are urgently needed for both clinical and research purposes. …

Background: AD is characterized by cerebral deposition of β-amyloid plaques with amyloid β-peptide
(Aβ) 42 as the major peptide constituent, along with neurofibrillary tangles and …

Background: AN1792 (beta-amyloid [Aβ]1–42) immunization reduces Aβ plaque burden
and preserves cognitive function in APP transgenic mice. The authors report the results of a …

Objective: To estimate the age-specific incidence rate of mild cognitive impairment (MCI)
according to sex and educational level and to explore the course of MCI, particularly its …

Objective Whereas cognitive deficits are known to be detectable long before the typical
symptoms of Alzheimer's disease (AD) are evident, previous studies have failed to determine …

Background and Purpose— Based on the hypothesis of glutamate-induced neurotoxicity (excitotoxicity)
in cerebral ischemia, this study examined the efficacy and tolerability of …

Alcoholism is a possible cause of dementia, mainly through associated nutritional deficiencies
and, rarely, through acute direct toxicity. However alcohol consumption was not found to …

… , the European Medicine Evaluation Agency EMEA) issued new guidelines for trials of
symptomatic treatments in Alzheimer's disease EMEA, 1997) and vascular dementia Orgogozo …