Pharmacokinetics of captopril in healthy subjects and in patients with cardiovascular diseases

KL Duchin, DN McKinstry, AI Cohen… - Clinical …, 1988 - Springer
Captopril, the first orally active inhibitor of angiotensin-converting enzyme, is used widely in
the treatment of hypertension and congestive heart failure. The pharmacokinetics of this …

Captopril kinetics

KL Duchin, SM Singhvi, DA Willard… - Clinical …, 1982 - Wiley Online Library
Captopril, an angiotensin‐converting enzyme inhibitor with antihypertensive properties, was
given by mouth and intravenously in 10‐mg doses to five healthy subjects. After intravenous …

Ischemia and tubule obstruction during acute renal failure in dogs: mannitol in protection

TJ Burke, RE Cronin, KL Duchin… - American Journal …, 1980 - journals.physiology.org
The pathogenetic factors involved in norepinephrine- (NE) induced reversible acute renal
failure (ARF) were examined in untreated (U) and mannitol-treated (M) animals. At 3 and 24 h …

Pharmacokinetics of fosinopril in patients with various degrees of renal function

KK Hui, KL Duchin, KJ Kripalani, D Chan… - Clinical …, 1991 - Wiley Online Library
Single‐dose kinetics of fosinopril, a new phosphorus‐containing angiotensin‐converting
enzyme inhibitor and its active diacid, fosinoprilat, were investigated in patients with mild, …

Disposition of fosinopril sodium in healthy subjects.

SM Singhvi, KL Duchin, RA Morrison… - British journal of …, 1988 - Wiley Online Library
… salt (Figure 1), and is hydrolysedin healthy subjects (Duchin et al., 1984,1985). It the body to
the … The primary objectives of this study in healthy hypertension (Duchin, 1986). This drug is …

Nadolol in human serum and breast milk.

RG Devlin, KL Duchin, PM Fleiss - British Journal of Clinical …, 1981 - Wiley Online Library
1 Simultaneous serum and milk samples were collected over a 10‐day period from twelve
normotensive, lactating subjects who ingested 80 mg nadolol once daily for a period of 5 days…

Once-daily fosinopril in the treatment of hypertension.

RJ Anderson, KL Duchin, RD Gore, TS Herman… - …, 1991 - Am Heart Assoc
This multicenter, dose-ranging study evaluated the antihypertensive effectiveness of once-daily
administration of fosinopril sodium in 220 patients with supine diastolic blood pressure of …

Phase I trial of orally administered pentosan polysulfate in patients with advanced cancer.

…, J Hanfelt, MK Yunmbam, JX Sun, KL Duchin… - Clinical cancer research …, 1997 - AACR
Tumor angiogenesis is critically important to tumor growth and metastasis. We have shown
that pentosan polysulfate (PPS) is an effective inhibitor of heparin-binding growth factors in …

Pharmacokinetics, safety, and pharmacologic effects of fosinopril sodium, an angiotensin‐converting enzyme inhibitor in healthy subjects

KL Duchin, AP Waclawski, JI Tu… - The Journal of …, 1991 - Wiley Online Library
The pharmacokinetics, pharmacodynamics, and safety of fosinopril sodium (SQ 28,555), a
new orally active angiotensin‐converting enzyme (ACE) inhibitor, was evaluated in 73 healthy …

Renal handling of captopril: effect of probenecid

SM Singhvi, KL Duchin, DA Willard… - Clinical …, 1982 - Wiley Online Library
14 C‐Captopril was given intravenously to four normal subjects in a 4‐mg priming dose
followed by constant intravenous infusion of 1.7 mg/hr for 3.5 hr with and without concomitant …