Background An evolving understanding of the immunopathogenesis of multiple sclerosis
suggests that depleting B cells could be useful for treatment. We studied ocrelizumab, a …

Background B cells influence the pathogenesis of multiple sclerosis. Ocrelizumab is a humanized
monoclonal antibody that selectively depletes CD20+ B cells. Methods In two identical …

Immune evasion is a hallmark of cancer. Losing the ability to present neoantigens through
human leukocyte antigen (HLA) loss may facilitate immune evasion. However, the …

Background Cladribine provides immunomodulation through selective targeting of lymphocyte
subtypes. We report the results of a 96-week phase 3 trial of a short-course oral tablet …

Background Fingolimod has shown reductions in clinical and MRI disease activity in patients
with relapsing-remitting multiple sclerosis. We further assessed the efficacy and safety of …

With the use of a mouse model expressing human Fc-gamma receptors (FcγRs), we
demonstrated that antibodies with isotypes equivalent to ipilimumab and tremelimumab mediate …

Importance Emergence of SARS-CoV-2 causing COVID-19 prompted the need to gather
information on clinical outcomes and risk factors associated with morbidity and mortality in …

… KW Rammohan1, … Dr KW Rammohan, Department of Neurology Ohio State University, 449
Means Hall, 1654 Upham Drive, Columbus, Ohio 43210 Columbus, Ohio, USA; rammohan.2{…

We examined the role of the complement system in the pathogenesis of dermatomyositis.
Using an antibody against the neoantigens of the terminal C5b–9 membrane attack complex, …

CD25 is expressed at high levels on regulatory T (Treg) cells and was initially proposed as
a target for cancer immunotherapy. However, anti-CD25 antibodies have displayed limited …