Abstract Machine learning and data mining techniques have been used in numerous real-world
applications. An assumption of traditional machine learning methodologies is the …

Persons with multiple chronic conditions are a large and growing segment of the US population.
However, little is known about how chronic conditions cluster, and the ramifications of …

The copper metabolism disorder Wilson's disease was first defined in 1912. Wilson's disease
can present with hepatic and neurological deficits, including dystonia and parkinsonism. …

One hallmark of Alzheimer disease is the accumulation of amyloid β-peptide in the brain
and its deposition as plaques. Mice transgenic for an amyloid β precursor protein (APP) mini-…

Background Immune checkpoint blockade therapy has shown promising results in patients
with advanced hepatocellular carcinoma. We aimed to assess the efficacy and safety of …

Background Clostridium difficile infection is a serious diarrheal illness associated with
substantial morbidity and mortality. Patients generally have a response to oral vancomycin or …

This paper provides support for the certification role of venture capitalists in initial public
offerings. Consistent with the certification hypothesis, a comparison of venture capital backed …

Background Chronic obstructive pulmonary disease (COPD) is a growing cause of morbidity
and mortality worldwide, and accurate estimates of the prevalence of this disease are …

BACKGROUND: In 1995, the Global Initiative for Asthma (GINA) guidelines recommended
goals for the management of asthma, which were updated in 2002. However, there are no …

… If conditions in our population change in such a way that the hazard of death from cause k
… in health (either a reduction in risk from cause k or a decrease in the total number of causes) …