Runx3/Pebp2αC null mouse gastric mucosa exhibits hyperplasias due to stimulated
proliferation and suppressed apoptosis in epithelial cells, and the cells are resistant to growth-…

Outside cells of the preimplantation mouse embryo form the trophectoderm (TE), a process
requiring the transcription factor Tead4. Here, we show that transcriptionally active Tead4 can …

The differentiation of mesenchymal cells into chondrocytes and chondrocyte proliferation
and maturation are fundamental steps in skeletal development. Runx2 is essential for …

The nonsense-mediated decay (NMD) pathway is an mRNA surveillance system that typically
degrades transcripts containing premature termination codons (PTCs) in order to prevent …

Peroxisome proliferator–activated receptors (PPARs) are members of the nuclear hormone
receptor superfamily and have a dominant regulatory role in adipocyte and monocyte …

The molecular mechanisms by which different mutations in the same gene can result in
distinct disease phenotypes remain largely unknown. Truncating mutations of SOX10 cause …

Background In preimplantation mouse embryos, the first cell fate specification to the
trophectoderm or inner cell mass occurs by the early blastocyst stage. The cell fate is controlled by …

Peroxisome proliferator-activated receptors (PPARs), members of the nuclear hormone
receptors superfamily, have an important regulatory role in adipogenesis and inflammation. …

Dorsal root ganglion (DRG) neurons specifically project axons to central and peripheral
targets according to their sensory modality. The Runt-related genes Runx1 and Runx3 are …

▪ Abstract Genomic rearrangements play a major role in the pathogenesis of human genetic
diseases. Nonallelic homologous recombination (NAHR) between low-copy repeats (LCRs) …