Radiotelemetry of mouse blood pressure accurately monitors systolic pressure, diastolic
pressure, heart rate, and locomotor activity but requires surgical implantation. Noninvasive …

We rescued the embryonic lethality of global PPARγ knockout by breeding Mox2-Cre (MORE)
mice with floxed PPARγ mice to inactivate PPARγ in the embryo but not in trophoblasts …

… Natale JE, D’Alecy LG. Protection from cerebral ischemia by … Natale JE, Stante SM, D’Alecy
LG. Elevated brain lactate … Facktor MA, Mayor GH, Nachreiner RF, D’Alecy LG. Thyroid …

… Lundy EF, Dykstra J, Luyckx BA, Zelenock GB, D'Alecy LG: Reduction of neurologic deficit
… Moursi MM, Luyckx BA, D'Alecy LG: The role of ethanol in diluents of drugs that protect mice …

The myofilament protein troponin I (TnI) has a key isoform-dependent role in the
development of contractile failure during acidosis and ischemia. Here we show that cardiac …

Prolylcarboxypeptidase (PRCP) activates prekallikrein to plasma kallikrein, leading to bradykinin
liberation, and degrades angiotensin II. We now identify PRCP as a regulator of blood …

Background— The nitric oxide synthase inhibitor asymmetrical dimethylarginine (ADMA)
and the leukocyte-derived hemoprotein myeloperoxidase (MPO) are associated with …

Severe, intermittent hypoxia (hypoxic conditioning) induces an acute adaptation such that
survival time during a subsequent hypoxic challenge is increased. The opiold antagonist, …

Background. Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of endothelial
nitric oxide synthase and a proposed cardiovascular risk factor, is elevated in chronic kidney …

Femoral artery blood samples from 30 unanesthetized unrestrained nonpanting dogs were
analyzed. Average normal pH was 7.42 (sd 0.03), mean Po2 89.5 mm Hg (sd 4.4), and Pco2 …