Electrical and synaptic integration of glioma into neural circuits
…, D Silverbush, SM Gillespie, M Arzt, LT Tam… - Nature, 2019 - nature.com
High-grade gliomas are lethal brain cancers whose progression is robustly regulated by
neuronal activity. Activity-regulated release of growth factors promotes glioma growth, but this …
neuronal activity. Activity-regulated release of growth factors promotes glioma growth, but this …
Targeting neuronal activity-regulated neuroligin-3 dependency in high-grade glioma
HS Venkatesh, LT Tam, PJ Woo, J Lennon, S Nagaraja… - Nature, 2017 - nature.com
High-grade gliomas (HGG) are a devastating group of cancers, and represent the leading
cause of brain tumour-related death in both children and adults. Therapies aimed at …
cause of brain tumour-related death in both children and adults. Therapies aimed at …
A comprehensive proteome map of growing Bacillus subtilis cells
…, J Bernhardt, D Becher, S Gentner, LT Tam… - …, 2004 - Wiley Online Library
The proteome of growing cells of Bacillus subtilis was analyzed in order to provide the basis
for its application in microbial physiology. DNA arrays were used to calculate the number of …
for its application in microbial physiology. DNA arrays were used to calculate the number of …
[PDF][PDF] Methotrexate chemotherapy induces persistent tri-glial dysregulation that underlies chemotherapy-related cognitive impairment
Chemotherapy results in a frequent yet poorly understood syndrome of long-term neurological
deficits. Neural precursor cell dysfunction and white matter dysfunction are thought to …
deficits. Neural precursor cell dysfunction and white matter dysfunction are thought to …
[HTML][HTML] Maladaptive myelination promotes generalized epilepsy progression
…, C Soane, A Batra, T Saucedo, E Frost, LT Tam… - Nature …, 2022 - nature.com
Activity-dependent myelination can fine-tune neural network dynamics. Conversely, aberrant
neuronal activity, as occurs in disorders of recurrent seizures (epilepsy), could promote …
neuronal activity, as occurs in disorders of recurrent seizures (epilepsy), could promote …
[HTML][HTML] Rationale-based engineering of a potent long-acting FGF21 analog for the treatment of type 2 diabetes
Fibroblast growth factor 21 (FGF21) is a promising drug candidate for the treatment of type 2
diabetes. However, the use of wild type native FGF21 is challenging due to several …
diabetes. However, the use of wild type native FGF21 is challenging due to several …
[HTML][HTML] Access to rural credit markets in developing countries, the case of Vietnam: A literature review
Agricultural sectors play an important role in the process of economic development of a
country, especially in developing ones. Vietnam is known as an emerging market, which …
country, especially in developing ones. Vietnam is known as an emerging market, which …
Understanding the Physical Interactions in the FGF21/FGFR/β‐Klotho Complex: Structural Requirements and Implications in FGF21 Signaling
J Yie, W Wang, L Deng, LT Tam… - Chemical biology & …, 2012 - Wiley Online Library
The endocrine fibroblast growth factor 21 (FGF21) requires both fibroblast growth factor
receptor (FGFR) and β‐Klotho for signaling. In this study, we sought to understand the inter‐…
receptor (FGFR) and β‐Klotho for signaling. In this study, we sought to understand the inter‐…
MRI radiogenomics of pediatric medulloblastoma: a multicenter study
Background Radiogenomics of pediatric medulloblastoma (MB) offers an opportunity for MB
risk stratification, which may aid therapeutic decision making, family counseling, and …
risk stratification, which may aid therapeutic decision making, family counseling, and …
Differential gene expression in response to phenol and catechol reveals different metabolic activities for the degradation of aromatic compounds in Bacillus subtilis
LT Tam, C Eymann, D Albrecht… - Environmental …, 2006 - Wiley Online Library
Aromatic organic compounds that are present in the environment can have toxic effects or
provide carbon sources for bacteria. We report here the global response of Bacillus subtilis …
provide carbon sources for bacteria. We report here the global response of Bacillus subtilis …