TYROBP (also known as DAP12 or KARAP) is a transmembrane adaptor protein initially
described as a receptor-activating subunit component of natural killer (NK) cells. TYROBP is …

… In the D9-N171-98Q mouse, instability is also more pronounced in the striatum than in
the cerebellum and tail (Brown and Ehrlich, unpublished data), implicating cell-autonomous …

Investigators have long suspected that pathogenic microbes might contribute to the onset
and progression of Alzheimer's disease (AD) although definitive evidence has not been …

We report the discovery of a mutation in the THAP1 gene in three Amish-Mennonite families
with mixed-onset primary torsion dystonia (also known as DYT6 dystonia). Another mutation …

Traumatic brain injury (TBI) is an unfortunately common event in military life. The conflicts in
Iraq and Afghanistan have increased public awareness of TBI in the military. Certain injury …

The turnover and processing of the Alzheimer beta/A4 amyloid precursor protein (beta APP)
has been studied in PC12 cells after treatment with agents that regulate protein …

Dystonia is a movement disorder characterized by repetitive twisting muscle contractions and
postures 1 , 2 . Its molecular pathophysiology is poorly understood, in part owing to limited …

We present a consensus atlas of the human brain transcriptome in Alzheimer's disease (AD),
based on meta-analysis of differential gene expression in 2,114 postmortem samples. We …

Alzheimer’s disease (AD), the most common form of dementia, is recognized as a heterogeneous
disease with diverse pathophysiologic mechanisms. In this study, we interrogate the …

Most common genetic risk variants associated with neuropsychiatric disease are noncoding
and are thought to exert their effects by disrupting the function of cis regulatory elements (…