… MJ Janssen and AEP Cantineau independently selected the trials to be included according
to the above mentioned criteria. We resolved disagreements by consensus or through …

Innovation systems and transitions thinking have become increasingly pervasive in what
has been labelled a third generation of challenge-led innovation and transitions policy …

Rather than merely supporting R&D and strengthening innovation systems, the focus of
innovation policy is currently shifting towards addressing societal challenges by transforming …

Missions may be regarded as a narrative for challenge-oriented policies, as a rationale for
directional policies, and as an instrument for coordinating distributed innovation efforts. While …

Although the development of new services is becoming a major concern for firms throughout
the entire economy, there is only little insight in the organizational antecedents of service …

Medium spiny neurons (MSNs) provide the principal output for the dorsal striatum. Those
that express dopamine D 2 receptors (D 2 + ) project to the globus pallidus external and are …

Neuregulin 1 (NRG-1) and its receptor ErbB4 have emerged as biologically plausible
schizophrenia risk factors, modulators of GABAergic and dopaminergic neurotransmission, and as …

Objective: Drug exposure during critical periods of brain development may adversely affect
nervous system function, posing a challenge for treating infants. This is of particular concern …

Nephropathic cystinosis is a severe, monogenic systemic disorder that presents early in life
and leads to progressive organ damage, particularly affecting the kidneys. It is caused by …

In the currently emerging paradigm of challenge-led and transformative innovation policies,
there is increasing attention for addressing urgent societal problems by formulating clear, …