User profiles for M. L. Wynn

Michelle L Wynn

Google X
Verified email at umich.edu
Cited by 481

Logic-based models in systems biology: a predictive and parameter-free network analysis method

ML Wynn, N Consul, SD Merajver… - Integrative biology, 2012 - academic.oup.com
Highly complex molecular networks, which play fundamental roles in almost all cellular
processes, are known to be dysregulated in a number of diseases, most notably in cancer. As a …

The importance of accurately correcting for the natural abundance of stable isotopes

FS Midani, ML Wynn, S Schnell - Analytical biochemistry, 2017 - Elsevier
The use of isotopically labeled tracer substrates is an experimental approach for measuring
in vivo and in vitro intracellular metabolic dynamics. Stable isotopes that alter the mass but …

Safety and efficacy of delayed intraarterial urokinase therapy with mechanical clot disruption for thromboembolic stroke.

…, TT Nguyen, OR O'Neill, ML Wynn… - American Journal …, 1994 - Am Soc Neuroradiology
… therapy, usually with 500 mL of a colloid solution, and … was then infused in 1-mL volumes
(50 000 U/mL) as a bolus into the … a gentle pulse spray of 0.10 mL, delivering 1 mL over 5 to 10 …

Running faster causes disaster: trade-offs between speed, manoeuvrability and motor control when running around corners in northern quolls (Dasyurus hallucatus)

ML Wynn, C Clemente, AFAA Nasir… - Journal of …, 2015 - journals.biologists.com
Movement speed is fundamental to all animal behaviour, yet no general framework exists
for understanding why animals move at the speeds they do. Even during fitness-defining …

Safety and efficacy of percutaneous transluminal angioplasty for intracranial atherosclerotic stenosis

WM Clark, SL Barnwell, G Nesbit, OR O'neill, ML Wynn… - Stroke, 1995 - Am Heart Assoc
Background and Purpose Percutaneous transluminal angioplasty (PCTA) is increasingly used
to treat extracerebral arterial stenosis. The present study evaluates the safety and efficacy …

[HTML][HTML] Adipocytes promote pancreatic cancer cell proliferation via glutamine transfer

…, CN Lumeng, CA Lyssiotis, ML Wynn… - … and biophysics reports, 2016 - Elsevier
… μg/ml insulin, 0.25 μM dexamethasone, 2 μM rosiglitazone for 3 days, followed by culture in
DMEM, 10%FCS, 1 μg/ml insulin … Final media volume was raised to 1 ml per manufacturer's …

[HTML][HTML] Kinase inhibitors can produce off-target effects and activate linked pathways by retroactivity

ML Wynn, AC Ventura, JA Sepulchre, HJ García… - BMC systems …, 2011 - Springer
Background It has been shown in experimental and theoretical work that covalently modified
signaling cascades naturally exhibit bidirectional signal propagation via a phenomenon …

Follow-the-leader cell migration requires biased cell–cell contact and local microenvironmental signals

ML Wynn, P Rupp, PA Trainor, S Schnell… - Physical …, 2013 - iopscience.iop.org
… The ABM used in this work was an extension of a simulation framework previously developed
(Wynn et al 2012). While the ABM presented here differs from the two ABMs previously …

Sex-specific trade-offs and compensatory mechanisms: bite force and sprint speed pose conflicting demands on the design of geckos (Hemidactylus frenatus)

SF Cameron, ML Wynn… - Journal of Experimental …, 2013 - journals.biologists.com
One of the more intuitive viability costs that can result from the possession of exaggerated
sexually selected traits is increased predation pressure as a result of reduced locomotor …

[HTML][HTML] RhoC GTPase is a potent regulator of glutamine metabolism and N-acetylaspartate production in inflammatory breast cancer cells

ML Wynn, JA Yates, CR Evans… - Journal of Biological …, 2016 - ASBMB
… /ml insulin, 0.5 μg/ml hydrocortisone, 0.02 μg/ml epidermal growth factor, and 0.1 μg/ml cholera
… with 5% FBS, 5 μg/ml insulin, and 1 μg/ml hydrocortisone. Cells were grown in 5% CO 2 …