Calciphylaxis is a rare and life-threatening complication that is estimated to occur in 1% of
patients with ESRD each year. Typically, extensive microvascular calcification and occlusion/…

Diagnosis of the type of glomerular disease that causes the nephrotic syndrome is necessary
for appropriate treatment and typically requires a renal biopsy. The goal of this study was to …

We present a case of acute, symptomatic hyponatremia in a young woman that developed
after use of 3,4-methylenedioxymethylamphetamine (MDMA), more commonly known as “…

Background. Nephrogenic systemic fibrosis is a debilitating disease occurring exclusively in
patients with renal failure. The aetiology of nephrogenic systemic fibrosis is unclear, but …

We evaluated 52 renal grafts transplanted into 41 patients with a pretransplantation diagnosis
of Alport's syndrome. Overall 1-, 5-, and 10-year patient and graft survival rates were 95.1…

Podocytes have limited ability to recover from injury. Here, we demonstrate that increased
mitochondrial biogenesis, to meet the metabolic and energy demand of a cell, accelerates …

Intraglomerular renin-angiotensin system enzyme activities have been examined previously
using glomerular lysates and immune-based assays. However, preparation of glomerular …

Reactive oxygen species (ROS) are increasingly believed to be important intracellular
signaling molecules in mitogenic pathways involved in the pathogenesis of glomerulonephritis (…

Transforming growth factor–β (TGF-β) is known to play a critical role in the pathogenesis of
many progressive podocyte diseases. However, the molecular mechanisms regulating TGF-β …

Introduction Tubular dysfunction is characteristic of Dent’s disease; however, focal segmental
glomerulosclerosis (FSGS) can also be present. Glomerulosclerosis could be secondary to …