User profiles for M. Hoshi

Masato Hoshi

Washington University School of Medicine
Verified email at wustl.edu
Cited by 2006

[HTML][HTML] Amyloid β-protein assembly and Alzheimer disease

R Roychaudhuri, M Yang, MM Hoshi… - Journal of Biological …, 2009 - ASBMB
The biochemistry of amyloid proteins has been a fascinating and important area of research
because of its contribution to our understanding of protein folding dynamics and assembly …

Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis

…, C Hillier, J Hobart, M Hoshi, SE Hunt, M Jagodic… - Nature …, 2013 - nature.com
Using the ImmunoChip custom genotyping array, we analyzed 14,498 subjects with multiple
sclerosis and 24,091 healthy controls for 161,311 autosomal variants and identified 135 …

An automated tool for detection of FLAIR-hyperintense white-matter lesions in multiple sclerosis

…, M Arsic, D Buck, A Förschler, A Berthele, M Hoshi… - Neuroimage, 2012 - Elsevier
In Multiple Sclerosis (MS), detection of T2-hyperintense white matter (WM) lesions on
magnetic resonance imaging (MRI) has become a crucial criterion for diagnosis and predicting …

Risk of Thyroid Cancer After Exposure to 131 I in Childhood

…, A Bouville, G Goulko, M Hoshi… - Journal of the …, 2005 - academic.oup.com
Background: After the Chernobyl nuclear power plant accident in April 1986, a large increase
in the incidence of childhood thyroid cancer was reported in contaminated areas. Most of …

Aβ (1–42) fibril structure illuminates self-recognition and replication of amyloid in Alzheimer's disease

…, S Parthasarathy, F Long, M Hoshi… - Nature structural & …, 2015 - nature.com
Increasing evidence has suggested that formation and propagation of misfolded aggregates
of 42-residue human amyloid β (Aβ(1–42)), rather than of the more abundant Aβ(1–40), …

Spherical aggregates of β-amyloid (amylospheroid) show high neurotoxicity and activate tau protein kinase I/glycogen synthase kinase-3β

M Hoshi, M Sato, S Matsumoto… - Proceedings of the …, 2003 - National Acad Sciences
β-Amyloid (Aβ) acquires toxicity by self-aggregation. To identify and characterize the toxic
form(s) of Aβ aggregates, we examined in vitro aggregation conditions by using large …

[HTML][HTML] Remarkable role of indoleamine 2, 3-dioxygenase and tryptophan metabolites in infectious diseases: potential role in macrophage-mediated inflammatory …

Y Murakami, M Hoshi, Y Imamura, Y Arioka… - Mediators of …, 2013 - hindawi.com
Indoleamine 2,3-dioxygenase 1 (IDO1), the L-tryptophan-degrading enzyme, plays a key role
in the immunomodulatory effects on several types of immune cells. Originally known for its …

Exposure of rat hippocampal neurons to amyloid β peptide (25–35) induces the inactivation of phosphatidyl inositol-3 kinase and the activation of tau protein kinase I …

…, K Noguchi, G Michel, M Mercken, M Hoshi… - Neuroscience …, 1996 - Elsevier
… No PIP 3 production was observed in culture treated with 10 -6 M wortmannin or Aft (25-35)
(20/~M), suggesting that PI-3 kinase activity was completely inhibited under these conditions …

Regulation of mitochondrial pyruvate dehydrogenase activity by tau protein kinase I/glycogen synthase kinase 3beta in brain.

M Hoshi, A Takashima, K Noguchi… - Proceedings of the …, 1996 - National Acad Sciences
According to the amyloid hypothesis for the pathogenesis of Alzheimer disease, beta-amyloid
peptide (betaA) directly affects neurons, leading to neurodegeneration and tau …

Antioxidant activity of eugenol and related monomeric and dimeric compounds

M Ogata, M Hoshi, S Urano, T Endo - Chemical and Pharmaceutical …, 2000 - jstage.jst.go.jp
Materials and Methods Chemicals Caryophylli F [as was kindly supplied by Dr. T. Nishimura
of Teikyo University, Tokyo, Japan. Eugcnol was obtained from Tokyo Kasei Kogyo Co.(…