… data reporting an overall M:F incidence ratio of 1.49 (95% CI 1.41–1.57, p < 0.001) and an
overall M:F prevalence ratio of 1.48 (95% CI 1.45–1.51, p < 0.001) [9]. Both M:F incidence and …

Background Deep brain stimulation (DBS) is an established and effective treatment for
Parkinson's disease (PD). After surgery, a number of extensive programming sessions are …

Background Deep brain stimulation (DBS) is an effective treatment for essential tremor (ET)
and dystonia. After surgery, a number of extensive programming sessions are performed, …

… Our data delineate a novel form of human M endelian P arkinsonism, and provide further
evidence for abnormal synaptic vesicle recycling as a central theme in the pathogenesis. …

Freezing of gait (FOG) is a frequent, disabling symptom of Parkinson's disease (PD). FOG
usually lasts a few seconds. It refers to brief paroxysmal events during which a subject is …

BACKGROUND: Freezing of gait is a common cause of disability and falls in patients with
Parkinson's disease. We studied brain functional connectivity, by means of resting-state …

Background The variability in the clinical phenotype of Parkinson’s disease seems to suggest
the existence of several subtypes of the disease. To test this hypothesis we performed a …

Cognitive impairment is common in PD, even in early stages. The construct of mild cognitive
impairment has been used to identify clinically evident cognitive impairment without …

Introduction In PD, Mild Cognitive Impairment (PD-MCI) occurs since early stages of disease.
The aims were to assess presence of PD-MCI in untreated, drug-naive PD patients, and to …

Presynaptic terminals are metabolically active and accrue damage through continuous
vesicle cycling. How synapses locally regulate protein homeostasis is poorly understood. We …