The pathophysiology of Parkinson's disease is reviewed in light of recent advances in the
understanding of the functional organization of the basal ganglia (BG). Current emphasis is …

Progressive loss of the ascending dopaminergic projection in the basal ganglia is a
fundamental pathological feature of Parkinson's disease. Studies in animals and humans have …

Insight into the organization of the basal ganglia in the normal, parkinsonian and l-dopa-induced
dyskinesia states is critical for the development of newer and more effective therapies …

Background Olaparib, a poly(ADP-ribose) polymerase (PARP) inhibitor, has previously shown
efficacy in a phase 2 study when given in capsule formulation to all-comer patients with …

Background Olaparib, a poly (ADP-ribose) polymerase (PARP) inhibitor, has previously
been shown to extend progression-free survival versus placebo when given to patients with …

Activation of NF-κB is achieved by ubiquitination and proteasome-mediated degradation of
IκBα. We have detected modified IκBα, conjugated to the small ubiquitin-like protein SUMO-1, …

Up to 22 June 2022, 508 confirmed cases of monkeypox (MPX) have been reported in the
Madrid region of Spain, 99% are men (n = 503) with a median age of 35 years (range: 18–67). …

Parkinson's disease is a neurodegenerative process characterized by numerous motor and
nonmotor clinical manifestations for which effective, mechanism-based treatments remain …

The basal ganglia (BG) are a highly organized network, where different parts are activated for
specific functions and circumstances. The BG are involved in movement control, as well as …

Background/Aims: To investigate the possible role of HIV infection in the natural history of
chronic parenterally-acquired hepatitis C. Methods: A multicenter cross-sectional study was …