User profiles for M. Schaaf

Marcel Schaaf

Leiden University
Verified email at biology.leidenuniv.nl
Cited by 6129

LC3/GABARAP family proteins: autophagy‐(un) related functions

MBE Schaaf, TG Keulers, MA Vooijs… - The FASEB …, 2016 - Wiley Online Library
From yeast to mammals, autophagy is an important mechanism for sustaining cellular
homeostasis through facilitating the degradation and recycling of aged and cytotoxic components. …

Molecular mechanisms of glucocorticoid action and resistance

MJM Schaaf, JA Cidlowski - The Journal of steroid biochemistry and …, 2002 - Elsevier
The actions of glucocorticoid hormones are mediated by an intracellular receptor, the
glucocorticoid receptor (GR). The mechanism of action of this ligand-inducible transcription factor …

[HTML][HTML] Defining the role of the tumor vasculature in antitumor immunity and immunotherapy

MB Schaaf, AD Garg, P Agostinis - Cell death & disease, 2018 - nature.com
It is now well established that cancer cells co-exist within a complex environment with stromal
cells and depend for their growth and dissemination on tight and plastic interactions with …

Downregulation of BDNF mRNA and protein in the rat hippocampus by corticosterone

MJM Schaaf, J de Jong, ER de Kloet, E Vreugdenhil - Brain research, 1998 - Elsevier
Previously, we showed that corticosterone regulates BDNF mRNA levels in the hippocampus.
In the present study, we have investigated the time course and dose-dependency of this …

Corticosterone effects on BDNF expression in the hippocampus implications for memory formation

MJM Schaaf, ER De Kloet, E Vreugdenhil - Stress, 2000 - Taylor & Francis
… when administered to ADX animals (Schaaf et al., in press). However, after water maze
training, rats show increased BDNF mRNA expression in CAI at 1 hr after training (Schaaf et a]., …

A 5000-yr record of climate change in varved sediments from the oxygen minimum zone off Pakistan, Northeastern Arabian Sea

U Von Rad, M Schaaf, KH Michels, H Schulz… - Quaternary …, 1999 - Elsevier
The upper Holocene marine section from a kasten core taken from the oxygen minimum
zone off Karachi (Pakistan) at water depth 700 m contains continuously laminated sediments …

Glucocorticoid receptor variants: clinical implications

RH DeRijk, M Schaaf, ER De Kloet - The Journal of steroid biochemistry …, 2002 - Elsevier
Following exposure to stress, cortisol is secreted from the adrenal cortex under the control
of the hypothalamic-pituitary-adrenal axis (HPA-axis). Central in the regulation of the HPA-…

A human glucocorticoid receptor gene variant that increases the stability of the glucocorticoid receptor beta-isoform mRNA is associated with rheumatoid arthritis.

RH Derijk, MJ Schaaf, G Turner, NA Datson… - The Journal of …, 2001 - jrheum.org
OBJECTIVE: To study the occurrence and function of polymorphism in the human glucocorticoid
receptor (hGR) gene in rheumatoid arthritis (RA) and systemic lupus erythematosus (…

Preoperative lateralization of ACTH-secreting pituitary microadenomas by bilateral and simultaneous inferior petrosal venous sinus sampling

…, GP Chrousos, HM Schulte, M Schaaf… - … England Journal of …, 1985 - Mass Medical Soc
PREVIOUS reports have established the utility of selective catheterization of the inferior
petrosal sinus for determination of plasma ACTH concentrations in the diagnosis of pituitary-…

An affective disorder in zebrafish with mutation of the glucocorticoid receptor

…, D Strasser, HA Ingraham, MJM Schaaf… - Molecular …, 2013 - nature.com
… weeks CMS’); 50–90 min of 5 μM diazepam treatment (‘Diazepam 5 μM’); or 2 weeks of CMS
with 0.8 μM fluoxetine treatment (‘2 weeks CMS+Fluoxetine 0.8 μM’; n=3–9 fish per group; …