Spinal cord lesions in patients with clinically isolated syndrome: a powerful tool in diagnosis and prognosis

MH Sombekke, MP Wattjes, LJ Balk, JM Nielsen… - Neurology, 2013 - AAN Enterprises
Objective: Spinal cord (SC) lesions are frequently found in multiple sclerosis (MS), but are
rare in healthy aging and cerebrovascular patients. Our aim was to analyze the contribution of …

Relevance of spinal cord abnormalities to clinical disability in multiple sclerosis: MR imaging findings in a large cohort of patients

C Lukas, MH Sombekke, B Bellenberg, HK Hahn… - Radiology, 2013 - pubs.rsna.org
Purpose To determine whether spinal cord atrophy differs among disease subtypes in multiple
sclerosis (MS) and whether it offers diagnostic and clinical correlative information beyond …

Cervical spinal cord volume loss is related to clinical disability progression in multiple sclerosis

C Lukas, DL Knol, MH Sombekke… - Journal of Neurology …, 2015 - jnnp.bmj.com
Objective To examine the temporal evolution of spinal cord (SC) atrophy in multiple sclerosis
(MS), and its association with clinical progression in a large MS cohort. Methods A total of …

Infratentorial and spinal cord lesions: Cumulative predictors of long-term disability?

I Dekker, MH Sombekke, LJ Balk… - Multiple Sclerosis …, 2020 - journals.sagepub.com
Objective: The objective of the study was to determine whether early infratentorial and/or
spinal cord lesions are long-term cumulative predictors of disability progression in multiple …

HLA-DRB1* 1501 and spinal cord magnetic resonance imaging lesions in multiple sclerosis

MH Sombekke, C Lukas, JBA Crusius… - Archives of …, 2009 - jamanetwork.com
Background Multiple sclerosis (MS) is a heterogeneous neurologic disease with extensive
variation with respect to the most affected central nervous system region (brain vs spinal cord)…

Asymptomatic spinal cord lesions do not predict the time to disability in patients with early multiple sclerosis

I Dekker, MH Sombekke, BI Witte… - Multiple Sclerosis …, 2018 - journals.sagepub.com
Background: The presence of asymptomatic spinal cord (SC) lesions in patients with
clinically isolated syndrome (CIS) or relapsing-remitting multiple sclerosis (RRMS) predicts …

Relevance of IL7R genotype and mRNA expression in Dutch patients with multiple sclerosis

MH Sombekke, LF Van Der Voort… - Multiple Sclerosis …, 2011 - journals.sagepub.com
Background: The interleukin 7 receptor (IL7R) has been recognized as a susceptibility gene
for Multiple Sclerosis (MS). Analysis of rs6897932 (the most strongly MS-associated single …

Relationship between brain MRI lesion load and short-term disease evolution in non-disabling MS: a large-scale, multicentre study

…, C Polman, A Rovira, MH Sombekke… - Multiple Sclerosis …, 2011 - journals.sagepub.com
Background and Objectives: We evaluated clinical and conventional MRI features of a large
population of patients with non-disabling MS to identify potential markers of a benign …

Analysis of multiple candidate genes in association with phenotypes of multiple sclerosis

MH Sombekke, D Arteta… - Multiple Sclerosis …, 2010 - journals.sagepub.com
Multiple sclerosis is a heterogeneous neurological disease with varying degrees of severity.
The common hypothesis is that susceptibility to multiple sclerosis and its phenotype are …

Genetic correlations of brain lesion distribution in multiple sclerosis: an exploratory study

MH Sombekke, MM Vellinga… - American journal …, 2011 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: In MS, the total brain lesion volume and spatial distribution
of lesions across the brain vary widely among individual patients. We hypothesized that …