Introduction Alzheimer's Disease Neuroimaging Initiative (ADNI) is now in its 10th year. The
primary objective of the magnetic resonance imaging (MRI) core of ADNI has been to …

The purpose of this study was to use serial imaging to gain insight into the sequence of
pathologic events in Alzheimer's disease, and the clinical features associated with this sequence. …

To date, most diagnostic imaging comparisons between amyloid labelling ligands and other
imaging modalities have been between the use of amyloid labelling ligand 11 C Pittsburgh …

Data diversity is critical to success when training deep learning models. Medical imaging
data sets are often imbalanced as pathologic findings are generally rare, which introduces …

Objective: A workgroup commissioned by the Alzheimer's Association (AA) and the National
Institute on Aging (NIA) recently published research criteria for preclinical Alzheimer …

Introduction Our goal was to develop cut points for amyloid positron emission tomography (PET),
tau PET, flouro-deoxyglucose (FDG) PET, and MRI cortical thickness. Methods We …

Biomarkers of brain Aβ amyloid deposition can be measured either by cerebrospinal fluid
Aβ42 or Pittsburgh compound B positron emission tomography imaging. Our objective was to …

OBJECTIVE: To develop and validate a tool for Alzheimer's disease (AD) diagnosis in individual
subjects using support vector machine (SVM)-based classification of structural MR (sMR…

Task-free functional magnetic resonance imaging (TF-fMRI) has great potential for advancing
the understanding and treatment of neurologic illness. However, as with all measures of …

Background: Neurofibrillary tangles (NFTs), composed of hyperphosphorylated tau proteins,
are one of the pathologic hallmarks of Alzheimer disease (AD). We aimed to determine …