The production of ROS (reactive oxygen species) by mammalian mitochondria is important
because it underlies oxidative damage in many pathologies and contributes to retrograde …

Ischaemia-reperfusion injury occurs when the blood supply to an organ is disrupted and then
restored, and underlies many disorders, notably heart attack and stroke. While reperfusion …

A very early step in the response of mammalian cells to DNA double-strand breaks is the
phosphorylation of histone H2AX at serine 139 at the sites of DNA damage. Although the …

Epidemiological studies have documented a reduced prevalence of Alzheimer's disease
among users of nonsteroidal anti-inflammatory drugs (NSAIDs) 1 , 2 , 3 , 4 , 5 . It has been …

Activated macrophages undergo metabolic reprogramming, which drives their pro-inflammatory
phenotype, but the mechanistic basis for this remains obscure. Here, we demonstrate …

The RefSeq project at the National Center for Biotechnology Information (NCBI) maintains
and curates a publicly available database of annotated genomic, transcript, and protein …

Background Although statins reduce coronary and cerebrovascular morbidity and mortality
in middle-aged individuals, their efficacy and safety in elderly people is not fully established. …

‘Reactive oxygen species’ (ROS) is a generic term that defines a wide variety of oxidant
molecules with vastly different properties and biological functions that range from signalling to …

Raster3D Version 2.0 is a program suite for the production of photorealistic molecular
graphics images. The code is hardware independent, and is particularly suited for use in …

The Sir2 histone deacetylase functions as a chromatin silencer to regulate recombination,
genomic stability, and aging in budding yeast. Seven mammalian Sir2 homologs have been …