Background: ROC curves have become the standard for describing and comparing the
accuracy of diagnostic tests. Not surprisingly, ROC curves are used often by clinical chemists. …

… , or necrotic tissue (Obuchowski 2006); biochemical analysis of serum ferritin concentration
measured in µg l −1 (Obuchowski 2005)). This situation is further discussed in section 4.4. …

… Obuchowski and Bullen have performed a simulation study to determine the minimum
sample size needed in test–retest studies.44 They have determined that estimates of precision …

Praise for the First Edition"... the book is a valuable addition to the literature in the field, serving
as a much-needed guide for both clinicians and advanced students."—Zentralblatt MATH …

Sensitivity and specificity are the basic measures of accuracy of a diagnostic test; however,
they depend on the cut point used to define “positive” and “negative” test results. As the cut …

Although investigators in the imaging community have been active in developing and evaluating
quantitative imaging biomarkers (QIBs), the development and implementation of QIBs …

Current methods for estimating the accuracy of diagnostic tests require independence of the
test results in the sample. However, cases in which there are multiple test results from the …

The series, which will ultimately comprise 22 articles, is designed to progressively educate
radiologists in the methodologies of rigorous clinical research, from the most basic principles …

PURPOSE: To prospectively determine in patients with acute low back pain (LBP) or
radiculopathy, the magnetic resonance (MR) imaging findings, prognostic role of these findings, …

… Obuchowski, NA ‘Multireader, multimodality receiver operating characteristic curve studies:
hypothesis testing and sample size estimation using an analysis of variance approach with …