The Alzheimer Disease Genetics Consortium (ADGC) performed a genome-wide association
study of late-onset Alzheimer disease using a three-stage design consisting of a discovery …

Chronic traumatic encephalopathy is a progressive tauopathy that occurs as a consequence
of repetitive mild traumatic brain injury. We analysed post-mortem brains obtained from a …

The discovery that some cases of familial amyotrophic lateral sclerosis (FALS) are associated
with mutations in the gene encoding Cu/Zn superoxide dismutase (SOD1) has focused …

Huntington's disease (HD) is an autosomal dominant neurological disorder characterized
by progressive chorea, cognitive impairment and emotional disturbance 1 . The disease …

The key neuropathological features of Huntington's disease (HD) are neuronal loss and
astroglial proliferation in the striatum. Despite the lack of specificity of cell loss seen with …

An impairment of energy metabolism may underlie slow excitotoxic neuronal death in
neurodegenerative diseases. We therefore examined the effects of intrastriatal, subacute systemic, …

Huntington's disease (HD) is an incurable and fatal hereditary neurodegenerative disorder
of mid-life onset characterized by chorea, emotional distress, and progressive cognitive …

Importance Players of American football may be at increased risk of long-term neurological
conditions, particularly chronic traumatic encephalopathy (CTE). Objective To determine the …

Blast exposure is associated with traumatic brain injury (TBI), neuropsychiatric symptoms,
and long-term cognitive disability. We examined a case series of postmortem brains from US …

A distinct subpopulation of striatal aspiny neurons, containing the enzyme nicotinamide
adenine dinucleotide phosphate diaphorase, is preserved in the caudate nucleus in …