OBJECTIVE: There is still no general consensus in the literature regarding the role of extent
of glioma resection in improving patient outcome. Although the importance of resection in …

Little progress has been made in the treatment of gliomas during the past 25 years. One
reason is our poor understanding of the cell of origin in these tumors and of the mechanisms …

… Five classes of molecules are generally observed in brain spectra: N-acetylaspartate; free
… N Engl J Med 353:811–822, 2005 122. Sanai N, Berger MS: Glioma extent of resection and …

… SVZ astrocyte cultures were established from the lateral walls of the anterior horn (n = 3),
body (n = 2) and temporal horn (n = 3). Cells were incubated for 3 d with an adenovirus …

… Analysis and interpretation of data: Berger, Sanai. Drafting the article: … Sanai N, Berger
MS: Glioma extent of resection and its impact on patient outcome. Neurosurgery 62:753–766, …

… In tracing the ependymal islets of the paediatric human RMS with serial coronal reconstructions
(n = 3), we noted a decrease in calibre of the RMS from the proximal to distal limb (Fig. 4)…

Background Language sites in the cortex of the brain vary among patients. Language mapping
while the patient is awake is an intraoperative technique designed to minimize language …

… We conducted a cytoarchitectural and ultrastructural study in complete postmortem brains
(n = 7) and in postmortem (n = 42) and intraoperative tissue (n = 43) samples of the lateral …

The factors driving therapy resistance in diffuse glioma remain poorly understood. To
identify treatment-associated cellular and genetic changes, we analyzed RNA and/or DNA …

The progressive loss of CNS myelin in patients with multiple sclerosis (MS) has been
proposed to result from the combined effects of damage to oligodendrocytes and failure of …