User profiles for N. Tsankova

Nadejda Tsankova

Associate Professor, Mount Sinai
Verified email at mssm.edu
Cited by 10405

Epigenetic regulation in psychiatric disorders

N Tsankova, W Renthal, A Kumar… - Nature Reviews …, 2007 - nature.com
… The amino (N) termini of the histones face outward from the nucleosome complex. b | …
Enrichment of histone modifications such as acetylation and methylation (M) at histone N-terminal …

Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress

…, W Renthal, SJ Russo, D Graham, NM Tsankova… - Science, 2006 - science.org
… zone by control mice (n = 18 mice), an effect suppressed after social defeat (n = 36 mice), …
24 hours and 4 weeks after 10 days of defeat stress (n = 13 or 14 mice). [Effect of social defeat …

Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action

NM Tsankova, O Berton, W Renthal, A Kumar… - Nature …, 2006 - nature.com
To better understand the molecular mechanisms of depression and antidepressant action,
we administered chronic social defeat stress followed by chronic imipramine (a tricyclic …

[PDF][PDF] Chromatin remodeling is a key mechanism underlying cocaine-induced plasticity in striatum

A Kumar, KH Choi, W Renthal, NM Tsankova… - Neuron, 2005 - cell.com
Given that cocaine induces neuroadaptations through regulation of gene expression, we
investigated whether chromatin remodeling at specific gene promoters may be a key …

[PDF][PDF] Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli

…, G Xiao, A Kumar, SJ Russo, A Graham, N Tsankova… - Neuron, 2007 - cell.com
Previous work has identified alterations in histone acetylation in animal models of drug
addiction and depression. However, the mechanisms which integrate drugs and stress with …

[HTML][HTML] Pathophysiology of SARS-CoV-2: the Mount Sinai COVID-19 autopsy experience

…, F Salem, MI Fiel, SM El Jamal, NM Tsankova… - Modern …, 2021 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its associated clinical
syndrome COVID-19 are causing overwhelming morbidity and mortality around the globe …

Histone modifications at gene promoter regions in rat hippocampus after acute and chronic electroconvulsive seizures

NM Tsankova, A Kumar, EJ Nestler - Journal of Neuroscience, 2004 - Soc Neuroscience
… is the normalized Ct value of H4 [Ct(H4)/Ct(Input)] or of H3 [Ct(H3)/Ct(Input)], Nave is the
mean N value for the control, and Ctave is the mean Ct value for the control. Fold differences (…

Pathophysiology of SARS-CoV-2: targeting of endothelial cells renders a complex disease with thrombotic microangiopathy and aberrant immune response. The …

…, F Salem, MI Fiel, SM El Jamal, NM Tsankova… - MedRxiv, 2020 - medrxiv.org
BACKGROUND Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) and its
associated clinical syndrome COVID-19 are causing overwhelming morbidity and mortality …

Phenotypic heterogeneity and plasticity of isocortical and hippocampal astrocytes in the human brain

AA Sosunov, X Wu, NM Tsankova… - Journal of …, 2014 - Soc Neuroscience
To examine the diversity of astrocytes in the human brain, we immunostained surgical
specimens of temporal cortex and hippocampus and autopsy brains for CD44, a plasma …

A qPCR ScoreCard quantifies the differentiation potential of human pluripotent stem cells

…, S Chetty, CA Gifford, L Daheron, NM Tsankova… - Nature …, 2015 - nature.com
… Correlations to the overall differentiation potential 2D and 2D efficiency for all lambdas with
n nonzero coefficients were averaged to obtain one correlation value for all fits with n markers…