Nitric oxide pathways in Alzheimer's disease and other neurodegenerative dementias

T Togo, O Katsuse, E Iseki - Neurological research, 2004 - Taylor & Francis
Nitric oxide (NO) is an enzymatic product of nitric oxide synthase (NOS). NO has significant
physiological functions and an increasing body of evidence suggests that NO pathways are …

Concurrence of TDP-43, tau and α-synuclein pathology in brains of Alzheimer's disease and dementia with Lewy bodies

…, M Minegishi, H Hino, K Fujisawa, T Togo, O Katsuse… - Brain research, 2007 - Elsevier
TAR-DNA-binding protein 43 (TDP-43) has been identified as a major component protein of
ubiquitin-positive inclusions in brains from patients with frontotemporal lobar degeneration …

Neuropathologic Features of Frontotemporal Lobar Degeneration With Ubiquitin-Positive Inclusions With Progranulin Gene (PGRN) Mutations

KA Josephs, Z Ahmed, O Katsuse… - … of Neuropathology & …, 2007 - academic.oup.com
Frontotemporal lobar degeneration is heterogeneous; cases with tau- and synuclein-negative,
ubiquitin-positive neuronal inclusions are the most common, and some have mutations in …

Atypical progressive supranuclear palsy with corticospinal tract degeneration

KA Josephs, O Katsuse… - … of Neuropathology & …, 2006 - academic.oup.com
Progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), sporadic multisystem
tauopathy, and some forms of frontotemporal dementia with Parkinsonism linked to …

Developmental stages of cortical Lewy bodies and their relation to axonal transport blockage in brains of patients with dementia with Lewy bodies

O Katsuse, E Iseki, W Marui, K Kosaka - Journal of the neurological …, 2003 - Elsevier
We investigated 10 dementia with Lewy bodies (DLB) brains showing various degrees of Lewy
pathology using α-synuclein-immunohistochemistry, and morphologically divided cortical …

Neuronal and glial accumulation of α-and β-synucleins in human lipidoses

K Suzuki, E Iseki, T Togo, A Yamaguchi, O Katsuse… - Acta …, 2007 - Springer
A number of the lysosomal storage diseases that have now been characterized are associated
with intra-lysosomal accumulation of lipids, caused by defective lysosomal enzymes. We …

Abnormal localization of leucine-rich repeat kinase 2 to the endosomal-lysosomal compartment in lewy body disease

…, M Minegishi, K Sato, T Togo, O Katsuse… - … of Neuropathology & …, 2009 - academic.oup.com
Missense mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most common
causes of both familial and sporadic forms of Parkinson disease and are also associated …

Localization of MAP1-LC3 in vulnerable neurons and Lewy bodies in brains of patients with dementia with Lewy bodies

…, T Kabuta, T Togo, O Katsuse… - … of Neuropathology & …, 2011 - academic.oup.com
There is emerging evidence implicating a role for the autophagy-lysosome pathway in the
pathogenesis of Lewy body disease. We investigated potential neuropathologic and …

Distribution of cerebral amyloid deposition and its relevance to clinical phenotype in Lewy body dementia

…, K Kasanuki, N Murayama, T Togo, O Katsuse… - Neuroscience …, 2010 - Elsevier
Parkinson's disease dementia (PDD) and dementia with Lewy bodies (DLB) are clinically
distinguished based only on the duration of parkinsonism prior to dementia. It is known that …

Clinical features of argyrophilic grain disease: a retrospective survey of cases with neuropsychiatric symptoms

…, H Akatsu, K Suzuki, H Uchikado, O Katsuse… - The American journal of …, 2005 - Elsevier
Objective Although argyrophilic grain disease (AGD) appears common in post-mortem series,
its clinical features are not widely known. The aim of this study was to explore such clinical …