State-of-the-art tissue-clearing methods provide subcellular-level optical access to intact
tissues from individual organs and even to some entire mammals. When combined with light-…

BACKGROUND: Catamenial pneumothorax is a rare entity of spontaneous, recurring
pneumothorax in women. It has been associated with thoracic endometriosis, yet varying clinical …

Tissue clearing and light-sheet microscopy have a 100-year-plus history, yet these fields
have been combined only recently to facilitate novel experiments and measurements in …

A long-standing goal of biology is to map the behavior of all cells during vertebrate
embryogenesis. We developed digital scanned laser light sheet fluorescence microscopy and …

Brain function relies on communication between large populations of neurons across
multiple brain areas, a full understanding of which would require knowledge of the time-varying …

BACKGROUND AND PURPOSE: MR venography is often used to examine the intracranial
venous system, particularly in the evaluation of dural sinus thrombosis. The purpose of this …

Recording light-microscopy images of large, nontransparent specimens, such as developing
multicellular organisms, is complicated by decreased contrast resulting from light scattering. …

Live imaging of large biological specimens is fundamentally limited by the short optical
penetration depth of light microscopes. To maximize physical coverage, we developed the …

Pushing the frontier of fluorescence microscopy requires the design of enhanced
fluorophores with finely tuned properties. We recently discovered that incorporation of four-membered …

Rho GTPases (20 human members) comprise a major branch of the Ras superfamily of
small GTPases, and aberrant Rho GTPase function has been implicated in oncogenesis and …