Nanoparticles (NP) are solid colloidal particles ranging in size from 1 to 1000 nm that are
utilized as drug delivery agents. The use of NPs to deliver drugs to the brain across the blood-…

Iron accumulation or iron overload in brain is commonly associated with neurodegenerative
disorders such as Parkinson’s and Alzheimer’s diseases, and also plays a role in cellular …

Choline has many physiological functions throughout the body that are dependent on its
available local supply. However, since choline is a charged hydrophilic cation, transport …

… 1A: 1.20 ^ 0.48 £ 1022 ml/g) agrees with previously published data for an intact BBB (Lockman
et al., 2003a,b). Subsequent experiments shown in Fig. 1A with neutral NPs present in …

Purpose: Brain metastases of breast cancer appear to be increasing in incidence, confer
significant morbidity, and threaten to compromise gains made in systemic chemotherapy. The …

Despite the advances in tumor therapy, patients with primary brain tumors and brain metastases
have a very poor prognosis. Low responses to chemotherapy are mainly attributed to …

Recently, a novel nanoparticle (NP) comprised of emulsifying wax and Brij 78 was shown to
have significant brain uptake using the in-situ rat brain perfusion technique. To further these …

Purpose We evaluated the uptake of angiopep-2 paclitaxel conjugate, ANG1005, into brain
and brain metastases of breast cancer in rodents. Most anticancer drugs show poor delivery …

Purpose. Two novel types of nanoparticles were evaluated as potential carriers for drugs
across the blood–brain barrier (BBB). Methods. Nanoparticles were composed of …

Metal ions accumulate in the brain with aging and in several neurodegenerative diseases.
Aside from the copper storage disease, Wilson's disease, recent attention has focused on the …