… Bos, R. et al. Biologic correlates of 18 fluorodeoxyglucose uptake in human breast cancer
… Gatenby, RA & Vincent, TL An evolutionary model of carcinogenesis. Cancer Res. 63, 6212–…

“Radiomics” refers to the extraction and analysis of large amounts of advanced quantitative
imaging features with high throughput from medical images obtained with computed …

We propose that carcinogenesis requires tumour populations to surmount six distinct
microenvironmental proliferation barriers that arise in the adaptive landscapes of normal and …

… where R is the ratio of emissions from the 2 channels, R A is the maximal ratio (observed
at acidic endpoint); R B is the minimal ratio (observed at the alkaline endpoint), and [(F B(λ2))/(…

… E, we see that r 3 ≈ d 3 (H core − H 0 ) / K 2 . Assuming a core pH of 6.4, we get r 3 ≈ 2.2 ×
… Gatenby RA. The potential role of transformation-induced metabolic changes in tumor-host …

Oxygen distribution was measured in 31 fixed lymph node metastases (mean diameter 4.4
cm ± 0.8 cm) from squamous cell carcinoma of the head and neck by passing a needle …

A number of successful systemic therapies are available for treatment of disseminated
cancers. However, tumor response is often transient, and therapy frequently fails due to …

Environment-mediated drug resistance is a form of de novo drug resistance that protects
tumour cells from the initial effects of diverse therapies. Surviving foci of residual disease can …

… Gillies RJ, Gatenby RA. Adaptive landscapes and emergent phenotypes: why do cancers …
Gillies RJ, Gatenby RA. Hypoxia and adaptive landscapes in the evolution of carcinogenesis…

The external pH of solid tumors is acidic as a consequence of increased metabolism of
glucose and poor perfusion. Acid pH has been shown to stimulate tumor cell invasion and …