The mechanistic target of rapamycin (mTOR) coordinates eukaryotic cell growth and metabolism
with environmental inputs, including nutrients and growth factors. Extensive research …

Cytokines are secreted signalling proteins that play essential roles in the initiation, maintenance
and resolution of immune responses. Although the unique ability of cytokines to control …

Observational astronomy of tidal disruption events (TDEs) began with the detection of X-ray
flares from quiescent galaxies during the ROSAT all-sky survey of 1990–1991. The flares …

Aims.We report on the production of a large area, shallow, sky survey, from XMM-Newton
slews. The great collecting area of the mirrors coupled with the high quantum efficiency of the …

Leucine is a proteogenic amino acid that also regulates many aspects of mammalian
physiology, in large part by activating the mTOR complex 1 (mTORC1) protein kinase, a master …

Aims. Pointed observations with XMM-Newton provide the basis for creating catalogues of X-ray
sources detected serendipitously in each field. This paper describes the creation and …

Amino acids signal to the mTOR complex I (mTORC1) growth pathway through the Rag
GTPases. Multiple distinct complexes regulate the Rags, including GATOR1, a GTPase …

Context. Thanks to the large collecting area (3 ×~1500 cm 2 at 1.5 keV) and wide field of
view (30′ across in full field mode) of the X-ray cameras on board the European Space …

… final working and free residuals, R work and R free , of 19.6% and 22.3%, respectively (table
S1). Sestrin2 crystallized in acubic space group containing five copies per asymmetric unit. …

The mechanistic target of rapamycin complex 1 (mTORC1) kinase is a major regulator of cell
growth that responds to numerous environmental cues. A key input is amino acids, which …