Outwitting the blood-brain barrier for therapeutic purposes: osmotic opening and other means
RA Kroll, EA Neuwelt - Neurosurgery, 1998 - journals.lww.com
OBJECTIVE: This article reviews historical aspects of the blood-brain barrier (BBB) and recent
advances in mechanisms to deliver therapeutic agents across the BBB for the treatment of …
advances in mechanisms to deliver therapeutic agents across the BBB for the treatment of …
A positron emission tomography study of silent and oral single word reading in stuttering and nonstuttering adults
LFD Nil, RM Kroll, S Kapur, S Houle - Journal of Speech, Language, and …, 2000 - ASHA
Over the last decade positron emission tomography (PET) has been used extensively for the
study of language and other cognitive and sensorimotor processes in healthy and diseased …
study of language and other cognitive and sensorimotor processes in healthy and diseased …
A positron emission tomography study of short-and long-term treatment effects on functional brain activation in adults who stutter
LF De Nil, RM Kroll, SJ Lafaille, S Houle - Journal of fluency disorders, 2003 - Elsevier
Previous studies have shown that fluency-inducing techniques, such as choral speech, result
in changes in neural activation as measured by functional neuroimaging. In the present …
in changes in neural activation as measured by functional neuroimaging. In the present …
A voxel-based morphometry (VBM) analysis of regional grey and white matter volume abnormalities within the speech production network of children who stutter
It is well documented that neuroanatomical differences exist between adults who stutter and
their fluently speaking peers. Specifically, adults who stutter have been found to have more …
their fluently speaking peers. Specifically, adults who stutter have been found to have more …
Improving drug delivery to intracerebral tumor and surrounding brain in a rodent model: a comparison of osmotic versus bradykinin modification of the blood-brain and …
RA Kroll, MA Pagel, LL Muldoon… - …, 1998 - journals.lww.com
OBJECTIVE: To compare transient blood-brain barrier disruption (BBBD) by hypertonic
mannitol with pharmacological modification of the blood-tumor barrier by the vasoactive peptide …
mannitol with pharmacological modification of the blood-tumor barrier by the vasoactive peptide …
Functional neuroimaging of cerebellar activation during single word reading and verb generation in stuttering and nonstuttering adults
F Luc, RM Kroll, S Houle - Neuroscience letters, 2001 - Elsevier
Articulatory discoordinations typically observed in fluent and disfluent speech of stuttering
adults suggest an underlying deficiency in the precise timing needed for speech production. …
adults suggest an underlying deficiency in the precise timing needed for speech production. …
Delayed administration of sodium thiosulfate in animal models reduces platinum ototoxicity without reduction of antitumor activity
LL Muldoon, MA Pagel, RA Kroll, RE Brummett… - Clinical Cancer …, 2000 - AACR
Platinum-based chemotherapeutic agents, such as carboplatin and cisplatin, are effective
against many human tumors, but their use may be limited by a high incidence of ototoxicity. …
against many human tumors, but their use may be limited by a high incidence of ototoxicity. …
The effects of simulated stuttering and prolonged speech on the neural activation patterns of stuttering and nonstuttering adults
Functional magnetic resonance imaging was used to investigate the neural correlates of
passive listening, habitual speech and two modified speech patterns (simulated stuttering and …
passive listening, habitual speech and two modified speech patterns (simulated stuttering and …
First evidence of otoprotection against carboplatin-induced hearing loss with a two-compartment system in patients with central nervous system malignancy using …
…, ND Doolittle, LL Muldoon, RA Kroll… - … of Pharmacology and …, 1998 - ASPET
Sodium thiosulfate (STS) provides protection against carboplatin-induced ototoxicity in an
animal model. The purpose of this study was to determine the STS dose required for …
animal model. The purpose of this study was to determine the STS dose required for …
Comparison of intracerebral inoculation and osmotic blood-brain barrier disruption for delivery of adenovirus, herpesvirus, and iron oxide particles to normal rat brain.
LL Muldoon, G Nilaver, RA Kroll, MA Pagel… - The American journal …, 1995 - ncbi.nlm.nih.gov
Delivery of adenovirus, herpes simplex virus (HSV), and paramagnetic monocrystalline iron
oxide nanoparticles (MION) to rat brain (n= 64) was assessed after intracerebral inoculation …
oxide nanoparticles (MION) to rat brain (n= 64) was assessed after intracerebral inoculation …