A malignant tumor is not merely an accumulation of neoplastic cells, but constitutes a
microenvironment containing endothelial cells, fibroblasts, structural components, and infiltrating …

miRNAs are responsible for post-transcriptional control of gene expression, and are frequently
downregulated in cancer. It has become well established that restoring miRNA levels can …

Caudal epidural block is a commonly used technique for surgical anesthesia in children and
chronic pain management in adults. It is performed by inserting a needle through the sacral …

Reactive microglia associated with the β-amyloid plaques in Alzheimer's disease (AD)
brains initiate a sequence of inflammatory events integral to the disease process. We have …

Current drought information is based on indices that do not capture the joint behaviors of
hydrologic variables. To address this limitation, the potential of copulas in characterizing …

The presence of cell-free microRNAs (miRNAs) has been detected in a range of body fluids.
The miRNA content of plasma/serum in particular has been proposed as a potential source …

Background TargomiRs are minicells (EnGeneIC Dream Vectors) loaded with miR-16-based
mimic microRNA (miRNA) and targeted to EGFR that are designed to counteract the loss of …

Amyloid-β peptide (Aβ) aggregate in senile plaque is a key characteristic of Alzheimer's
disease (AD). Here, we show that phosphorylation of amyloid precursor protein (APP) on …

Cell-free microRNAs in plasma and serum have become a promising source of biomarkers
for various diseases. Despite rapid progress in this field, there remains a lack of consensus …

Drought is a natural hazard that can have severe and long-lasting impacts on natural and
human systems. Although increases in global greenhouse forcing are expected to change the …