Pan-cancer analyses that examine commonalities and differences among various cancer
types have emerged as a powerful way to obtain novel insights into cancer biology. Here we …

Primitive neuroectodermal tumors of the central nervous system (CNS-PNETs) are highly
aggressive, poorly differentiated embryonal tumors occurring predominantly in young children …

… Finally, data from this study may also give hints for different cellular origin(s) of ATRTs and
will form the basis for the development of mouse models recapitulating the ATRT subgroups. …

Background Medulloblastoma is associated with rare hereditary cancer predisposition
syndromes; however, consensus medulloblastoma predisposition genes have not been defined …

… Animals were subjected to weekly bioluminescence imaging, and when tumors were clearly
detectable (signals in the range of 105–106 rad/s), mice with equivalent bioluminescent …

… A pediatric pathologist (BC) evaluated PDOX tumors in comparison with primary human
tumor for all samples obtained from Seattle Children’s and Children’s Oncology Group samples …

Embryonal tumours with multilayered rosettes (ETMRs) are aggressive paediatric embryonal
brain tumours with a universally poor prognosis 1 . Here we collected 193 primary ETMRs …

… kit (#69504) according to the manufacturer’s instructions. Tumor RNA was extracted with
TRIzol reagent according to the manufacturer’s instructions (ThermoFisher, #15596026). RNA …

Patient-derived tumor xenograft (PDX) mouse models have emerged as an important oncology
research platform to study tumor evolution, mechanisms of drug response and resistance…

Purpose Children with histologically diagnosed high-risk medulloblastoma, supratentorial
primitive neuroectodermal tumor of the CNS (CNS-PNET), and pineoblastoma (PBL) have had …