Regulation of µ-opioid receptors: desensitization, phosphorylation, internalization, and tolerance
Morphine and related µ-opioid receptor (MOR) agonists remain among the most effective
drugs known for acute relief of severe pain. A major problem in treating painful conditions is …
drugs known for acute relief of severe pain. A major problem in treating painful conditions is …
On the front line: Frontal zones as priority at‐sea conservation areas for mobile marine vertebrates
Identifying priority areas for marine vertebrate conservation is complex because species of
conservation concern are highly mobile, inhabit dynamic habitats and are difficult to monitor. 2…
conservation concern are highly mobile, inhabit dynamic habitats and are difficult to monitor. 2…
Endogenous opioid peptides in the descending pain modulatory circuit
EE Bagley, SL Ingram - Neuropharmacology, 2020 - Elsevier
The opioid epidemic has led to a serious examination of the use of opioids for the treatment
of pain. Opioid drugs are effective due to the expression of opioid receptors throughout the …
of pain. Opioid drugs are effective due to the expression of opioid receptors throughout the …
How opioids inhibit GABA-mediated neurotransmission
The midbrain region periaqueductal grey (PAG) is rich in opioid receptors and endogenous
opioids and is a major target of analgesic action in the central nervous system 1 . It has been …
opioids and is a major target of analgesic action in the central nervous system 1 . It has been …
Fhit, a Putative Tumor Suppressor in Humans, Is a Dinucleoside 5',5' ''-P1,P3-Triphosphate Hydrolase
…, A Guranowski, AK Robinson, SW Ingram… - Biochemistry, 1996 - ACS Publications
Human Fhit (fragile histidine triad) protein, encoded by the FHIT putative tumor suppressor
gene, is a typical dinucleoside 5‘,5‘ ‘‘-P 1 ,P 3 -triphosphate (Ap 3 A) hydrolase (EC 3.6.1.29) …
gene, is a typical dinucleoside 5‘,5‘ ‘‘-P 1 ,P 3 -triphosphate (Ap 3 A) hydrolase (EC 3.6.1.29) …
Identifying critical areas and habitat preferences of bottlenose dolphins Tursiops truncatus
We present the findings of a 2-yr study of habitat use by bottlenose dolphins in the outer
Shannon estuary on the west coast of Ireland. Data were collected during repeated, …
Shannon estuary on the west coast of Ireland. Data were collected during repeated, …
Linking futures across scales: a dialog on multiscale scenarios
Scenario analysis is a useful tool for exploring key uncertainties that may shape the future of
social-ecological systems. This paper explores the methods, costs, and benefits of …
social-ecological systems. This paper explores the methods, costs, and benefits of …
Dopamine transporter–mediated conductances increase excitability of midbrain dopamine neurons
… Responses were averaged over the last 20 s of approximately 2–3 min drug superfusion.
Rate histograms were generated by counting the spike number in 10-s intervals. …
Rate histograms were generated by counting the spike number in 10-s intervals. …
Ultrawideband indoor positioning systems and their use in emergencies
SJ Ingram, D Harmer, M Quinlan - PLANS 2004. position …, 2004 - ieeexplore.ieee.org
… We will cover both a general-purpose system installed as part of a building’s infrastructure,
and a rapidly deployed ad-hoc system for use in emergencies. We then consider how UWB …
and a rapidly deployed ad-hoc system for use in emergencies. We then consider how UWB …
Glimmer: Multilevel MDS on the GPU
We present Glimmer, a new multilevel algorithm for multidimensional scaling designed to
exploit modern graphics processing unit (GPU) hardware. We also present GPU-SF, a parallel, …
exploit modern graphics processing unit (GPU) hardware. We also present GPU-SF, a parallel, …