[PDF][PDF] Neue Entwicklungen in der Demenzdiagnostik

GW Eschweiler, T Leyhe, S Klöppel, M Hüll - Deutsches Ärzteblatt, 2010 - researchgate.net
… Conclusion: The early, preclinical phase of Alzheimer’s disease involves what has been …
s disease correctly in this phase can be raised above 80%. Early detection of Alzheimer’s

CAG repeat expansion in Huntington disease determines age at onset in a fully dominant fashion

…, EY Kim, M Kimble, P King, ML Klimek, S Klöppel… - Neurology, 2012 - AAN Enterprises
Objective: Age at onset of diagnostic motor manifestations in Huntington disease (HD) is
strongly correlated with an expanded CAG trinucleotide repeat. The length of the normal CAG …

Automatic classification of MR scans in Alzheimer's disease

S Klöppel, CM Stonnington, C Chu, B Draganski… - Brain, 2008 - academic.oup.com
To be diagnostically useful, structural MRI must reliably distinguish Alzheimer's disease (AD)
from normal aging in individual scans. Recent advances in statistical learning theory have …

Estimating the age of healthy subjects from T1-weighted MRI scans using kernel methods: exploring the influence of various parameters

K Franke, G Ziegler, S Klöppel, C Gaser… - Neuroimage, 2010 - Elsevier
The early identification of brain anatomy deviating from the normal pattern of growth and
atrophy, such as in Alzheimer's disease (AD), has the potential to improve clinical outcomes …

Consensus paper: combining transcranial stimulation with neuroimaging

…, L De Gennaro, AP Strafella, S Kähkönen, S Klöppel… - Brain stimulation, 2009 - Elsevier
In the last decade, combined transcranial magnetic stimulation (TMS)-neuroimaging studies
have greatly stimulated research in the field of TMS and neuroimaging. Here, we review …

Evidence for segregated and integrative connectivity patterns in the human basal ganglia

B Draganski, F Kherif, S Klöppel, PA Cook… - Journal of …, 2008 - Soc Neuroscience
… PICo involves repeated iterations of a streamline process using Monte Carlo methods to
model inherent uncertainty in the orientation of the principal diffusion direction(s) defined for …

Implementation of subjective cognitive decline criteria in research studies

…, KA Ellis, M Ewers, H Hampel, S Klöppel… - Alzheimer's & …, 2017 - Elsevier
… future, change in SCD may be one way of assessing longitudinal functional benefit in
secondary prevention trials [5], but there will need to a consensus on which particular measure(s) …

[HTML][HTML] BrainAGE in Mild Cognitive Impaired Patients: Predicting the Conversion to Alzheimer's Disease

C Gaser, K Franke, S Klöppel, N Koutsouleris, H Sauer… - PloS one, 2013 - journals.plos.org
Alzheimer’s disease (AD), the most common form of dementia, shares many aspects of
abnormal brain aging. We present a novel magnetic resonance imaging (MRI)-based biomarker …

Accuracy of dementia diagnosis—a direct comparison between radiologists and a computerized method

S Klöppel, CM Stonnington, J Barnes, F Chen, C Chu… - Brain, 2008 - academic.oup.com
… The SVM results are taken from our previously reported study for comparison (Kloppel et al.,
… 20 subjects are included from each diagnostic group (Kloppel et al., 2008a) but the number …

Combining functional and anatomical connectivity reveals brain networks for auditory language comprehension

…, H Küpper, P Kellmeyer, D Kümmerer, S Klöppel… - Neuroimage, 2010 - Elsevier
… However, in the case of fMRI with sampling rates of about 2 s, interactions must be regarded
as instantaneous, thus information of the past cannot be used to explain the direction of …