Validating the sensitivity of inhomogeneous magnetization transfer (ihMT) MRI to myelin with fluorescence microscopy

…, VH Prevost, M Cayre, A Hertanu, S Mchinda… - Neuroimage, 2019 - Elsevier
Inhomogeneous Magnetization Transfer (ihMT) is a development from the MT MRI technique.
IhMT can be considered as a dipolar order relaxation time (T 1D ) weighted imaging …

Whole brain inhomogeneous magnetization transfer (ihMT) imaging: sensitivity enhancement within a steady‐state gradient echo sequence

S Mchinda, G Varma, VH Prevost… - Magnetic resonance …, 2018 - Wiley Online Library
… This elementary sequence kernel (RF burst + readout) is repeated until a steady state is
reached and may be repeated as long as necessary to acquire a whole 3D volume, as for …

Evaluation of the sensitivity of inhomogeneous magnetization transfer (ihMT) MRI for multiple sclerosis

E Van Obberghen, S Mchinda… - American Journal …, 2018 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: Inhomogeneous magnetization transfer is a new endogenous
MR imaging contrast mechanism that has demonstrated high specificity for myelin. Here, …

Optimization of inhomogeneous magnetization transfer (ihMT) MRI contrast for preclinical studies using dipolar relaxation time (T1D) filtering

VH Prevost, OM Girard, S Mchinda, G Varma… - NMR in …, 2017 - Wiley Online Library
A pulsed inhomogeneous magnetization transfer (ihMT)‐prepared fast imaging sequence
was implemented at 11.75 T for preclinical studies on mouse central nervous system. A …

Low duty-cycle pulsed irradiation reduces magnetization transfer and increases the inhomogeneous magnetization transfer effect

G Varma, OM Girard, S Mchinda, VH Prevost… - Journal of Magnetic …, 2018 - Elsevier
Intense off-resonant RF irradiation can lead to saturation of the macromolecular pool
magnetization and enhance bound pool dipolar order responsible for the inhomogeneous …

MRI assessment of multiple dipolar relaxation time (T1D) components in biological tissues interpreted with a generalized inhomogeneous magnetization transfer …

VND Carvalho, A Hertanu, A Grélard, S Mchinda… - Journal of Magnetic …, 2020 - Elsevier
T 1 D , the relaxation time of dipolar order, is sensitive to slow motional processes. Thus T 1
D is a probe for membrane dynamics and organization that could be used to characterize …

Contribution of the MP2RAGE 7T sequence in MS lesions of the cervical spinal cord

…, N Fabiani, S Demortière, S Mchinda… - American Journal …, 2023 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: The detection of spinal cord lesions in patients with MS is
challenging. Recently, the 3D MP2RAGE sequence demonstrated its usefulness at 3T. …

A strategy to reduce the sensitivity of inhomogeneous magnetization transfer (ihMT) imaging to radiofrequency transmit field variations at 3 T

…, T Troalen, A Hertanu, S Mchinda… - Magnetic …, 2022 - Wiley Online Library
… Although the complete description of these effects is outside the scope of the present paper,
more information is provided in the Discussion section and Supporting Information, which is

Anisotropy of inhomogeneous magnetization transfer (ihMT) in white matter

OM Girard, VH Prevost, S Mchinda, G Varma… - Proc. Intl. Soc. Mag …, 2017 - hal.science
Inhomogeneous magnetization transfer (ihMT) is a new endogenous contrast mechanism that
has been proposed for imaging myelinated tissues. The dipolar interaction underlying the …

Validation of inhomogeneous magnetization transfer (ihMT) as a myelin biomarker

…, OM Girard, M Cayre, G Varma, S Mchinda… - Proc. Intl. Soc. Mag …, 2017 - hal.science
The ihMT (inhomogeneous Magnetization transfer) signal qualitatively demonstrates sensitivity
for myelinated structures. However, image intensity and contrast vary with the saturation …