Role of reactive oxygen species in LPS‐induced production of prostaglandin E2 in microglia

…, TE Eling, R Langenbach, S Taniura… - Journal of …, 2004 - Wiley Online Library
We determined the roles of reactive oxygen species (ROS) in the expression of cyclooxygenase‐2
(COX‐2) and the production of prostaglandin E 2 (PGE 2 ) in lipopolysaccharide (LPS)…

ERK signalling as a regulator of cell motility

S Tanimura, K Takeda - The Journal of Biochemistry, 2017 - academic.oup.com
… SH3 domain-containing protein 2 (SH3P2) was originally identified as one of the proteins
that contain an SH3 domain(s) but have no known function (53). Our group revealed that …

[HTML][HTML] A new protein containing an SH2 domain that inhibits JAK kinases

…, H Sakamoto, K Mitsui, A Matsumoto, S Tanimura… - Nature, 1997 - nature.com
… We confirmed that JAB bound to Jak2 in vitro using a recombinant fusion protein of
glutathione-S -transferase with the JAB SH2 domain (GST–SH2). As shown in Fig. 2a (upper panel, …

[HTML][HTML] Genotoxic stress abrogates renewal of melanocyte stem cells by triggering their differentiation

…, N Okamoto, S Tanimura, T Wakayama, S Iseki… - Cell, 2009 - cell.com
… However, the cause(s) underlying the aging phenomenon and the possible involvement
of the DNA-damage response in the appearance of EPMs have not been studied. …

[HTML][HTML] MDM2 interacts with MDMX through their RING finger domains

S Tanimura, S Ohtsuka, K Mitsui, K Shirouzu… - FEBS letters, 1999 - Elsevier
The N-terminus of MDM2 proto-oncoprotein interacts with p53 and down modulates p53 activity
by inhibiting transcriptional activity and promoting p53 degradation. MDMX is structurally …

[PDF][PDF] Hair follicle stem cells provide a functional niche for melanocyte stem cells

S Tanimura, Y Tadokoro, K Inomata, NT Binh, W Nishie… - Cell stem cell, 2011 - cell.com
… to promote each other’s maintenance. … ’s instructions. 3 mg total RNA was used for cDNA
synthesis in THERMOSCRIPT RT-PCR System (GIBCO) according to the manufacturer’s

Targeting the extracellular signal-regulated kinase pathway in cancer therapy

M Kohno, S Tanimura, K Ozaki - Biological and Pharmaceutical …, 2011 - jstage.jst.go.jp
The extracellular signal-regulated kinase (ERK) pathway is a major determinant in the control
of diverse cellular processes such as proliferation, survival, and motility. This pathway is …

[PDF][PDF] Activity-dependent proteolytic cleavage of neuroligin-1

…, M Zeng, S Tanimura, Y Nishiyama, S Osawa… - Neuron, 2012 - cell.com
Neuroligin (NLG), a postsynaptic adhesion molecule, is involved in the formation of synapses
by binding to a cognate presynaptic ligand, neurexin. Here we report that neuroligin-1 (…

Cloning and characterization of novel CIS family genes

…, H Yasukawa, K Mitsui, T Wakioka, S Tanimura… - Biochemical and …, 1997 - Elsevier
We have reported two JAK-signaling modulators, CIS (cytokine-inducible SH2 protein) and
JAB (JAK2 binding protein), which are structurally related. Here we cloned three additional …

Freezing water in no-man's land

A Manka, H Pathak, S Tanimura, J Wölk… - Physical Chemistry …, 2012 - pubs.rsc.org
… of the condensible p v′ leading to a rapid increase in the vapor supersaturation S v = p
v /p eq . Once S v exceeds a critical value the vapor–liquid nucleation rate is high enough to …