Machine learning for precision medicine

SJ MacEachern, ND Forkert - Genome, 2021 - cdnsciencepub.com
Precision medicine is an emerging approach to clinical research and patient care that focuses
on understanding and treating disease by integrating multi-modal or multi-omics data from …

Activation of colonic mucosal 5-HT4 receptors accelerates propulsive motility and inhibits visceral hypersensitivity

JM Hoffman, K Tyler, SJ MacEachern, OB Balemba… - Gastroenterology, 2012 - Elsevier
BACKGROUND & AIMS: 5-hydroxytryptamine receptor (5-HT 4 R) agonists promote
gastrointestinal motility and attenuate visceral pain, but concerns about adverse reactions have …

Inhibiting inducible nitric oxide synthase in enteric glia restores electrogenic ion transport in mice with colitis

SJ MacEachern, BA Patel, CM Keenan, M Dicay… - Gastroenterology, 2015 - Elsevier
Background & Aims Disturbances in the control of ion transport lead to epithelial barrier
dysfunction in patients with colitis. Enteric glia regulate intestinal barrier function and colonic ion …

Nitric oxide regulation of colonic epithelial ion transport: a novel role for enteric glia in the myenteric plexus

SJ MacEachern, BA Patel, DM McKay… - The Journal of …, 2011 - Wiley Online Library
Non‐technical summary The enteric nervous system of the gastrointestinal tract regulates all
the functions of the gut. Enteric neurons are surrounded and outnumbered by enteric glial …

Association of pediatric acute-onset neuropsychiatric syndrome with microstructural differences in brain regions detected via diffusion-weighted magnetic resonance …

…, ES McKenna, NC Rowe, SJ MacEachern… - JAMA Network …, 2020 - jamanetwork.com
Importance Epidemiological studies indicate a link between obsessive-compulsive disorder
and infections, particularly streptococcal pharyngitis. Pediatric acute-onset neuropsychiatric …

Transient receptor potential vanilloid 4 inhibits mouse colonic motility by activating NO-dependent enteric neurotransmission

…, DP Poole, N Veldhuis, SJ MacEachern… - Journal of Molecular …, 2015 - Springer
Recent studies implicate TRPV4 receptors in visceral pain signaling and intestinal inflammation.
Our aim was to evaluate the role of TRPV4 in the control of gastrointestinal (GI) motility …

Alterations in melatonin and 5‐HT signalling in the colonic mucosa of mice with dextran‐sodium sulfate‐induced colitis

SJ MacEachern, CM Keenan… - British journal of …, 2018 - Wiley Online Library
Background and Purpose Inflammatory bowel disease (IBD) is characterized by pain,
bleeding, cramping and altered gastrointestinal (GI) function. Changes in mucosal 5‐HT (serotonin…

Children with epilepsy demonstrate macro-and microstructural changes in the thalamus, putamen, and amygdala

SJ MacEachern, JD Santoro, KJ Hahn, ZA Medress… - Neuroradiology, 2020 - Springer
Purpose Despite evidence for macrostructural alteration in epilepsy patients later in life, little
is known about the underlying pathological or compensatory mechanisms at younger ages …

[HTML][HTML] Electrochemical fecal pellet sensor for simultaneous real-time ex vivo detection of colonic serotonin signalling and motility

R Morris, A Fagan-Murphy, SJ MacEachern, D Covill… - Scientific reports, 2016 - nature.com
Various investigations have focused on understanding the relationship between mucosal
serotonin (5-HT) and colonic motility, however contradictory studies have questioned the …

[HTML][HTML] Cerebral volume and diffusion MRI changes in children with sensorineural hearing loss

…, NN Ng, J Zheng, LT Tam, SJ MacEachern… - Neuroimage: Clinical, 2020 - Elsevier
Purpose Sensorineural hearing loss (SNHL) is the most prevalent congenital sensory deficit
in children. Information regarding underlying brain microstructure could offer insight into …