Primary CNS lymphoma treated with osmotic blood-brain barrier disruption: prolonged survival and preservation of cognitive function.
…, J Crossen, F Ramsey, S Roman-Goldstein… - Journal of clinical …, 1991 - ascopubs.org
Combination chemotherapy with or without radiotherapy has had only modest efficacy in the
treatment of primary CNS lymphoma. Median survival of these patients, treated primarily …
treatment of primary CNS lymphoma. Median survival of these patients, treated primarily …
Improving drug delivery to intracerebral tumor and surrounding brain in a rodent model: a comparison of osmotic versus bradykinin modification of the blood-brain and …
…, MA Pagel, LL Muldoon, S Roman-Goldstein… - …, 1998 - journals.lww.com
OBJECTIVE: To compare transient blood-brain barrier disruption (BBBD) by hypertonic
mannitol with pharmacological modification of the blood-tumor barrier by the vasoactive peptide …
mannitol with pharmacological modification of the blood-tumor barrier by the vasoactive peptide …
MR of carcinoma-specific monoclonal antibody conjugated to monocrystalline iron oxide nanoparticles: the potential for noninvasive diagnosis.
…, CI McCormick, S Roman-Goldstein… - American Journal …, 1996 - Am Soc Neuroradiology
PURPOSE To determine if tumor-specific monoclonal antibodies conjugated to superparamagnetic
monocrystalline iron oxide nanoparticles can be used to yield specific diagnoses …
monocrystalline iron oxide nanoparticles can be used to yield specific diagnoses …
A physiological barrier distal to the anatomic blood-brain barrier in a model of transvascular delivery
…, RA Kroll, S Roman-Goldstein… - American journal …, 1999 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: Osmotic disruption of the blood-brain barrier (BBB)
provides a method for transvascular delivery of therapeutic agents to the brain. The apparent …
provides a method for transvascular delivery of therapeutic agents to the brain. The apparent …
Toxicity and efficacy of carboplatin and etoposide in conjunction with disruption of the blood-brain tumor barrier in the treatment of intracranial neoplasms
PC Williams, WD Henner, S Roman-Goldstein… - …, 1995 - journals.lww.com
CARBOPLATIN AND ETOPOSIDE have been investigated in preclinical studies and a limited
toxicity study in 13 patients; these studies have established carboplatin and etoposide as a …
toxicity study in 13 patients; these studies have established carboplatin and etoposide as a …
Increasing volume of distribution to the brain with interstitial infusion: dose, rather than convection, might be the most important factor
…, MA Pagel, LL Muldoon, S Roman-Goldstein… - …, 1996 - journals.lww.com
THE VOLUME OF distribution in tissue (V t) that can be achieved by direct interstitial infusion
of therapeutic agents into brain is limited. The maintenance of a pressure gradient during …
of therapeutic agents into brain is limited. The maintenance of a pressure gradient during …
MR of primary CNS lymphoma in immunologically normal patients.
SM Roman-Goldstein, DL Goldman… - American journal …, 1992 - Am Soc Neuroradiology
PURPOSE To describe the MR findings of primary CNS lymphoma. METHODS MR scans of
20 patients with histologically proved primary CNS lymphoma were reviewed. We evaluated …
20 patients with histologically proved primary CNS lymphoma were reviewed. We evaluated …
Delivery of virus-sized iron oxide particles to rodent CNS neurons
…, G Nilaver, RA Kroll, S Roman-Goldstein… - …, 1994 - journals.lww.com
DELIVERY OF VIRAL particles to the brain is limited by the volume of distribution that can be
obtained. Additionally, there is currently no way to non-invasively monitor the distribution of …
obtained. Additionally, there is currently no way to non-invasively monitor the distribution of …
White matter changes associated with feline GM2 gangliosidosis (Sandhoff disease): correlation of MR findings with pathologic and ultrastructural abnormalities.
…, MA Pagel, S Roman-Goldstein… - American journal …, 1995 - Am Soc Neuroradiology
PURPOSE To establish changes on MR of the brain in a feline model of Sandhoff disease in
order to develop standards by which this model may be used in future noninvasive studies. …
order to develop standards by which this model may be used in future noninvasive studies. …
The potential for complete and durable response in nonglial primary brain tumors in children and young adults with enhanced chemotherapy delivery.
…, A Petrillo, JR Crossen, S Roman-Goldstein… - The cancer journal …, 1998 - europepmc.org
Purpose Radiographic tumor response and survival were evaluated in the pediatric and
young adult population with germ cell tumor, primary CNS lymphoma, or primitive …
young adult population with germ cell tumor, primary CNS lymphoma, or primitive …