The role of MRI in the assessment of multiple sclerosis (MS) goes far beyond the diagnostic
process. MRI techniques can be used as regular monitoring to help stage patients with MS …

The clinical use of MRI in patients with multiple sclerosis (MS) has advanced markedly over
the past few years. Technical improvements and continuously emerging data from clinical …

MRI has improved the diagnostic work-up of multiple sclerosis, but inappropriate image
interpretation and application of MRI diagnostic criteria contribute to misdiagnosis. Some …

Using functional magnetic resonance imaging (fMRI) we have evaluated the anatomical
location of the motor hand area. The segment of the precentral gyrus that most often contained …

Background Progressive multifocal leukoencephalopathy (PML) was reported to have
developed in three patients treated with natalizumab. We conducted an evaluation to determine …

Objective: Brain microbleeds on gradient-recalled echo (GRE) T2*-weighted MRI may be a
useful biomarker for bleeding-prone small vessel diseases, with potential relevance for …

Background Oral fumarate (BG00012) might have dual anti-inflammatory and neuroprotective
effects. Our aim was to assess the efficacy and safety of BG00012 in patients with relapsing…

Functional magnetic resonance imaging blood-oxygenation-level-dependent (BOLD) signal
increases (activations) and BOLD signal decreases (“deactivations”) were compared in six …

Background: In a 2-year, placebo-controlled trial (the Natalizumab Safety and Efficacy in
Relapsing Remitting Multiple Sclerosis [AFFIRM] study), involving 942 patients with relapsing …

Unfixed and fixed postmortem multiple sclerosis (MS) brain is being used to probe pathology
underlying quantitative MR (qMR) changes. Effects of fixation on qMR indices in MS brain …