Neuromyelitis optica (NMO) is an inflammatory CNS syndrome distinct from multiple
sclerosis (MS) that is associated with serum aquaporin-4 immunoglobulin G antibodies (AQP4-IgG). …

… Prof Tanuja Chitnis, MD Tanuja Chitnis … -cell infiltration; by contrast, multiple sclerosis
lesions are characterised by infiltration by CD8 + T cells. …

Serum antibodies directed against myelin oligodendrocyte glycoprotein (MOG) are found in
patients with acquired CNS demyelinating syndromes that are distinct from multiple sclerosis …

Programmed death-1 (PD-1) receptor, an inhibitory costimulatory molecule found on activated
T cells, has been demonstrated to play a role in the regulation of immune responses and …

… T cells and monocytes from MS patients compared with healthy controls (Supplementary Fig.
11a–c). Ingenuity pathway analysis was used to identify altered canonical pathways. Both T …

Background: There has been tremendous growth in research in pediatric multiple sclerosis (MS)
and immune mediated central nervous system demyelinating disorders since …

… However, during the chronic stages of disease, T cell reactivity to host myelin peptides has
been observed, indicating epitope spreading has occurred secondary to T cell responses to …

Since its initial reports in the 19th century, neuromyelitis optica (NMO) had been thought to
involve only the optic nerves and spinal cord. However, the discovery of highly specific anti–…

Experimental autoimmune encephalomyelitis (EAE) is mediated by autoantigen-specific T
cells dependent on critical costimulatory signals for their full activation and regulation. We …

… activity between patients with RAW and patients with PIRA events, based on the number (negative
binomial model) and the percentage of patients free of gadolinium (Gd)-enhancing T …