[HTML][HTML] Prognostic significance of clinical, histopathological, and molecular characteristics of medulloblastomas in the prospective HIT2000 multicenter clinical trial …

…, DTW Jones, J Felsberg, K Kaulich, T Goschzik… - Acta …, 2014 - Springer
This study aimed to prospectively evaluate clinical, histopathological and molecular
variables for outcome prediction in medulloblastoma patients. Patients from the HIT2000 …

[HTML][HTML] Treatment of children and adolescents with metastatic medulloblastoma and prognostic relevance of clinical and biologic parameters.

…, M Mynarek, K Müller, T Goschzik… - Journal of clinical …, 2016 - folia.unifr.ch
English Purpose To assess an intensified treatment in the context of clinical and biologic
risk factors in metastatic medulloblastoma. Patients and Methods Patients (4 to 21 years old, …

Supratentorial ependymomas of childhood carry C11orf95RELA fusions leading to pathological activation of the NF-κB signaling pathway

T Pietsch, I Wohlers, T Goschzik, V Dreschmann… - Acta …, 2014 - Springer
Methods). This fusion was not detectable in a large series of infratentorial and spinal
ependymomas including myxopapillary ependymomas. It was also not detectable in …

[HTML][HTML] Prognostic effect of whole chromosomal aberration signatures in standard-risk, non-WNT/non-SHH medulloblastoma: a retrospective, molecular analysis of …

T Goschzik, EC Schwalbe, D Hicks, A Smith… - The lancet …, 2018 - thelancet.com
Background Most children with medulloblastoma fall within the standard-risk clinical
disease group defined by absence of high-risk features (metastatic disease, large-cell/anaplastic …

Genomic alterations of adamantinomatous and papillary craniopharyngioma

T Goschzik, M Gessi, V Dreschmann… - … of Neuropatholgy & …, 2017 - academic.oup.com
Craniopharyngiomas are rare histologically benign but clinically challenging neoplasms. To
obtain further information on the molecular genetics and biology of craniopharyngiomas, we …

FGFR1 Mutations in Rosette-Forming Glioneuronal Tumors of the Fourth Ventricle

…, YA Moneim, J Hammes, T Goschzik… - … of Neuropathology & …, 2014 - academic.oup.com
Rosette-forming glioneuronal tumors (RGNTs) are rare glioneuronal tumors of the fourth
ventricle region that preferentially affect young adults. Despite their histologic similarity with …

[HTML][HTML] Biomarker-driven stratification of disease-risk in non-metastatic medulloblastoma: Results from the multi-center HIT-SIOP-PNET4 clinical trial

…, D Hicks, K O'Toole, SL Nicholson, T Goschzik… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Purpose To improve stratification of risk-adapted treatment for non-metastatic (M0), standard-risk
medulloblastoma patients by prospective evaluation of biomarkers of reported …

Molecular stratification of medulloblastoma: comparison of histological and genetic methods to detect Wnt activated tumours

T Goschzik, A Zur Mühlen, G Kristiansen… - Neuropathology and …, 2015 - Wiley Online Library
Aims Wnt activation in medulloblastomas is associated with good outcome. Upfront testing
and risk‐adapted stratification of patients will be done in future clinical studies. In a cohort of …

[HTML][HTML] Identification of low and very high-risk patients with non-WNT/non-SHH medulloblastoma by improved clinico-molecular stratification of the HIT2000 and I-HIT …

…, K von Hoff, BO Juhnke, T Goschzik, T Pietsch… - Acta …, 2023 - Springer
… overall and 4/56 (7.1%) standard risk cases are included in both the HIT as well as the
published PNET cohort [9], allowing for validation of the WCA phenotypes identified by Goschzik

PTEN Mutations and Activation of the PI3K/Akt/mTOR Signaling Pathway in Papillary Tumors of the Pineal Region

T Goschzik, M Gessi, D Denkhaus… - … of Neuropathology & …, 2014 - academic.oup.com
Papillary tumors of the pineal region (PTPR) are recognized as a distinct entity in the World
Health Organization classification of CNS tumors. Papillary tumors of the pineal region …