User profiles for T. Hirano

Toshio Hirano

Osaka University and National Institutes for Quantum Science and Technology
Verified email at alumni.osaka-u.ac.jp
Cited by 80053

Biology of multifunctional cytokines: IL 6 and related molecules (IL 1 and TNF)

S Akira, T Hirano, T Taga, T Kishimoto - The FASEB journal, 1990 - Wiley Online Library
… Historically, IL 6 was probably first detected in T cell supernatants as a helper T cell factor
(or factors) that was observed to induce immunoglobulin secretion by B cells, the so-called …

Biological and clinical aspects of interleukin 6

T Hirano, S Akira, T Taga, T Kishimoto - Immunology today, 1990 - cell.com
… In this review, Toshio Hirano and colleagues discuss the possible involvement of IL-6 in a …
, and may play a central role in host defense mechanisms T.2. It was previously known as [32-…

IL-6 in inflammation, autoimmunity and cancer

T Hirano - International immunology, 2021 - academic.oup.com
… IL-6 on the diversity of T h 1 and T h 2 cells is not … T reg cells to T h 17 cells, and this process
is inhibited by IL-2. The IL-6/TGFβ and IL-2/TGFβ axes regulate the balance of T h 17 and T

Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin

T Hirano, K Yasukawa, H Harada, T Taga, Y Watanabe… - Nature, 1986 - nature.com
… We thank Professor T. Oi for advice on the homology search and Ms K. Hirano for preparation
of the manuscript. Supported by grants from the Ministry of Education, Science and Culture …

Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas

M Kawano, T Hirano, T Matsuda, T Taga, Y Horii… - Nature, 1988 - nature.com
… Human B cell stimulatory factor 2 (BSF-2) was originally charac-terized and isolated as a T
cell-derived … Responses are also seen in T cells 11,12 , plasmacytomas 6 , hepatocytes 7,13 , …

A nuclear factor for IL‐6 expression (NF‐IL6) is a member of a C/EBP family.

…, Y Nishio, T Nakajima, T Hirano, T Kishimoto - The EMBO …, 1990 - embopress.org
NF‐IL6 is a nuclear factor that specifically binds to an IL1‐responsive element in the IL‐6
gene. In this study the gene encoding NF‐IL6 has been cloned by direct screening of a lambda …

Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130

…, K Yasukawa, T Matsuda, T Hirano, T Kishimoto - Cell, 1989 - cell.com
… coupled to ovalbumin as described by Hirano et al. (1987). Antibody was affinity-purified …
Rabbit antiIL-6 antibody was prepared as described by Hirano et al. (1988). MT18 is a mouse …

[HTML][HTML] Condensins, chromosome condensation protein complexes containing XCAP-C, XCAP-E and a Xenopus homolog of the Drosophila Barren protein

T Hirano, R Kobayashi, M Hirano - Cell, 1997 - cell.com
We report here purification and characterization of chro- mosome condensation protein
complexes (termed condensins) containing XCAP-C and XCAP-E, two Xenopus members of the …

[HTML][HTML] Energy spectra of low-mass binary X-ray sources observed from TENMA

…, K Suzuki, Y Tanaka, T Hirano - … Society of Japan …, 1984 - adsabs.harvard.edu
Observations of X-ray spectra for four low-mass binary X-ray sources, Sco X-1, 4U 1608-522,
GX5-1 and GX349+ 2 were performed with the gas scintillation proportional counters on …

Molecular cloning and expression of an IL-6 signal transducer, gp130

…, M Murakami, M Saito, T Hirano, T Taga, T Kishimoto - Cell, 1990 - cell.com
… In fact, when transfected with IL-6-R cDNA, human Jurkat T cells and mouse L fibroblast cells
expressed both high and low affinity IL-6 binding sites, although the number of high affinity …