Nuclear transport and cancer: from mechanism to intervention

TR Kau, JC Way, PA Silver - Nature Reviews Cancer, 2004 - nature.com
Nuclear-cytoplasmic transport, which occurs through special structures called nuclear pores,
is an important aspect of normal cell function, and defects in this process have been …

Aortic development and anomalies

T Kau, M Sinzig, J Gasser, G Lesnik… - Seminars in …, 2007 - thieme-connect.com
ABSTRACT Development of the aorta takes place during the third week of gestation. It is a
complex process that can lead to a variety of congenital variants and pathological anomalies. …

Assessing the significance of chromosomal aberrations in cancer: methodology and application to glioma

…, JH Huang, S Alexander, J Du, T Kau… - Proceedings of the …, 2007 - National Acad Sciences
Comprehensive knowledge of the genomic alterations that underlie cancer is a critical
foundation for diagnostics, prognostics, and targeted therapeutics. Systematic efforts to analyze …

[HTML][HTML] A chemical genetic screen identifies inhibitors of regulated nuclear export of a Forkhead transcription factor in PTEN-deficient tumor cells

TR Kau, F Schroeder, S Ramaswamy… - Cancer cell, 2003 - cell.com
The PI3K/PTEN/Akt signal transduction pathway plays a key role in many tumors.
Downstream targets of this pathway include the Forkhead family of transcription factors (FOXO1a, …

Lung cancer in women: analysis of the national Surveillance, Epidemiology, and End Results database

JB Fu, TY Kau, RK Severson, GP Kalemkerian - Chest, 2005 - Elsevier
Objectives In order to further characterize the effect of gender on the clinicopathologic features
and survival of patients with lung cancer, and to determine gender-associated differences …

Nuclear transport as a target for cell growth

TR Kau, PA Silver - Drug Discovery Today, 2003 - Elsevier
… Interestingly however, several staurosporine-related compounds have been isolated in a
chemical genetic screen for inhibitors of FKHR nuclear export (TR Kau and PA Silver, …

Solenopsin, the alkaloidal component of the fire ant (Solenopsis invicta), is a naturally occurring inhibitor of phosphatidylinositol-3-kinase signaling and angiogenesis

JL Arbiser, T Kau, M Konar, K Narra, R Ramchandran… - Blood, 2007 - ashpublications.org
… SVR cells are murine endothelial cells immortalized by infection with an ecotropic retrovirus
encoding SV40 large T antigen, followed by transformation with oncogenic H-ras, and have …

Firefighter hand anthropometry and structural glove sizing: a new perspective

H Hsiao, J Whitestone, TY Kau, B Hildreth - Human factors, 2015 - journals.sagepub.com
Objective: We evaluated the current use and fit of structural firefighting gloves and developed
an improved sizing scheme that better accommodates the US firefighter population. …

Anthropometric criteria for the design of tractor cabs and protection frames

…, R Whisler, J Zwiener, C Lafferty, TY Kau… - Ergonomics, 2005 - Taylor & Francis
Improved human – tractor interface designs, such as well-accommodated operator enclosures
(ie cabs and protection frames) can enhance operator productivity, comfort and safety. …

US truck driver anthropometric study and multivariate anthropometric models for cab designs

J Guan, H Hsiao, B Bradtmiller, TY Kau… - Human …, 2012 - journals.sagepub.com
Objective: This study presents data from a large-scale anthropometric study of US truck
drivers and the multivariate anthropometric models developed for the design of next-generation …