IgG4-related disease (IgG4-RD) is an immunemediated fibroinflammatory condition that can
affect multiple organs and lead to tumefactive, tissuedestructive lesions and organ failure (1)…

… The Bcl-2 family are key regulators of apoptosis and are overexpressed in many
malignancies even without the presence of the t (14; 18) chromosomal translocations. Increased …

… For a subject let X ti denote the maximal diameter for lesion i at scan time t and Y ti the … is
X t 1 + ⋯ + X t k and the bi-dimensional measurement is X t 1 Y t 1 + ⋯ + X t k Y t k , where k is …

… Our group previously identified elevated serum cardiac troponin T (cTnT) as the most
powerful predictor of overall survival. Others have reported that N-terminal pro-brain natriuretic …

Background Radiation therapy as an adjunct to surgery for rectal cancer has been shown to
reduce local recurrence but has not improved survival. In a previous study, combined …

Objective To determine the clinical and laboratory features of newly diagnosed multiple
myeloma. Patients and Methods Records of all patients in whom multiple myeloma was initially …

The POEMS syndrome (coined to refer to polyneuropathy, organomegaly, endocrinopathy,
M protein, and skin changes) remains poorly understood. Ambiguity exists over the features …

Background Primary systemic amyloidosis is an uncommon disease characterized by the
accumulation in vital organs of a fibrillar protein consisting of monoclonal light chains. Methods …

Multiple myeloma remains an incurable neoplasm of plasma cells that affects more than
20,000 people annually in the United States. There has been a veritable revolution in this …

… to T cells and/or the synthesis of cytokines that sustain T cell memory.4 ,27 The response
to RTX among patients with IgG4-RD appears to be variable, with some patients having …