Valacyclovir and prednisolone treatment for Bell's palsy: a multicenter, randomized, placebo-controlled study

…, S Murakami, J Kiguchi, K Yamano, T Takeda… - Otology & …, 2007 - journals.lww.com
Objective: To investigate the effects of valacyclovir and prednisolone in comparison with
those of placebo and prednisolone for the treatment of Bell's palsy, excluding zoster sine …

Endolymphatic hydrops induced by chronic administration of vasopressin

T Takeda, S Takeda, H Kitano, T Okada, A Kakigi - Hearing research, 2000 - Elsevier
Recently, many lines of evidence have supported the possibilities that vasopressin (VP) is
closely linked to the formation of endolymphatic hydrops in Meniere’s disease. In the present …

Antidiuretic hormone (ADH) and endolymphatic hydrops

T Takeda, A Kakigi, H Saito - Acta oto-laryngologica, 1995 - Taylor & Francis
Plasma antidiuretic hormone (p-ADH) concentrations were determined with a radioimmunoassay,
using a reversed-phase C., silica column, in 300 patients with vertigo, dizziness and/or …

Expressions of aquaporin‐2, vasopressin type 2 receptor, transient receptor potential channel vanilloid (TRPV) 1, and TRPV4 in the human endolymphatic sac

D Taguchi, T Takeda, A Kakigi, M Takumida… - The …, 2007 - Wiley Online Library
Objective: To localize aquaporin (AQP)2, vasopressin type 2 receptor (V 2 ‐R), and
transient receptor potential channel vanilloid subfamily 1, 4 (TRPV1, TRPV4) in the human …

The effects of V2 antagonist (OPC-31260) on endolymphatic hydrops

T Takeda, S Sawada, S Takeda, H Kitano, M Suzuki… - Hearing research, 2003 - Elsevier
In the present study, two experiments were performed to investigate the influence of OPC-31260
on experimentally induced endolymphatic hydrops in guinea pigs and the regulation of …

Hormonal aspects of Meniere's disease on the basis of clinical and experimental studies

T Takeda, S Takeda, A Kakigi, T Okada… - ORL: Journal for Oto …, 2010 - karger.com
Conclusions: Endolymph homeostasis is thought to be mediated by the vasopressin-aquaporin-2
(VP-AQP2) system in the inner ear. Endolymphatic hydrops, the morphological …

Aquaporin-2 regulation by vasopressin in the rat inner ear

S Sawada, T Takeda, H Kitano, S Takeuchi, A Kakigi… - …, 2002 - journals.lww.com
Our previous studies have suggested a close relationship between vasopressin and
endolymphatic hydrops, or the increased volume of endolymph in the inner ear. Endolymphatic …

Aquaporins as potential drug targets for Meniere's disease and its related diseases

T Takeda, D Taguchi - Aquaporins, 2009 - Springer
The homeostasis of water in the inner ear is essential for maintaining function of hearing
and equilibrium. Since the discovery of aquaporin water channels, it has become clear that …

[HTML][HTML] Morphological and functional changes in a new animal model of Ménière's disease

N Egami, A Kakigi, T Sakamoto, T Takeda… - Laboratory …, 2013 - nature.com
The purpose of this study was to clarify the underlying mechanism of vertiginous attacks in
Ménière’s disease (MD) while obtaining insight into water homeostasis in the inner ear using …

Expression of aquaporin1, 3, and 4, NKCC1, and NKCC2 in the human endolymphatic sac

A Kakigi, M Nishimura, T Takeda, D Taguchi… - Auris Nasus …, 2009 - Elsevier
OBJECTIVE: To locate aquaporin (AQP) 1, 3, and 4, Na–K–2Cl cotransporter (NKCC) 1 and
2 in the human endolymphatic sac (ES). METHODS: A sample of human ES was harvested …