Vascular cognitive impairment

…, T Erkinjuntti, B Reisberg, G Roman, T Sawada… - The Lancet …, 2003 - thelancet.com
Cerebrovascular disease is the second most common cause of acquired cognitive impairment
and dementia and contributes to cognitive decline in the neurodegenerative dementias. …

Enlargement of spontaneous intracerebral hemorrhage: incidence and time course

S Kazui, H Naritomi, H Yamamoto, T Sawada… - Stroke, 1996 - Am Heart Assoc
Background and Purpose Standard radiographic criteria for hematoma enlargement have not
been established. We undertook this investigation to assess the incidence and time course …

Cilostazol for prevention of secondary stroke (CSPS 2): an aspirin-controlled, double-blind, randomised non-inferiority trial

…, M Tsushima, Y Koretsune, T Sawada… - The Lancet …, 2010 - thelancet.com
Background The antiplatelet drug cilostazol is efficacious for prevention of stroke recurrence
compared with placebo. We designed the second Cilostazol Stroke Prevention Study (…

Cilostazol stroke prevention study: a placebo-controlled double-blind trial for secondary prevention of cerebral infarction

…, Y Shinohara, E Itoh, T Matsuda, T Sawada… - Journal of Stroke and …, 2000 - Elsevier
Cilostazol, an antiplatelet drug that increases the cyclic adenosine monophosphate (AMP)
levels in platelets via inhibition of cyclic AMP phosphodiesterase, has been used in chronic …

Hemorrhagic transformation in cerebral embolism.

…, T Yamaguchi, K Minematsu, T Miyashita, T Sawada… - Stroke, 1989 - Am Heart Assoc
We studied the mechanism of hemorrhagic infarction after acute cerebral embolism in 160
patients by brain computed tomography and angiography. Hemorrhagic infarction during the …

Quinoline and benzimidazole derivatives: candidate probes for in vivo imaging of tau pathology in Alzheimer's disease

…, M Maruyama, H Arai, K Yanai, T Sawada… - Journal of …, 2005 - Soc Neuroscience
Neurofibrillary tangles (NFTs), neuropil threads, and neuritic elements of senile plaques
predominantly comprise hyperphosphorylated tau protein and represent pathological …

Role of insulin resistance associated with compensatory hyperinsulinemia in ischemic stroke

…, T Shimizu, M Suzuki, M Ikebuchi, T Sawada… - Stroke, 1996 - Am Heart Assoc
Background and Purpose Although insulin resistance and hyperinsulinemia play a crucial
role in the pathogenesis of atherosclerosis, little is known about their roles in ischemic stroke. …

Periventricular white matter lucency and cerebral blood flow autoregulation in hypertensive patients.

…, Y Kuriyama, K Nagatsuka, M Nakamura, T Sawada… - …, 1994 - Am Heart Assoc
The goal of this study was to elucidate the association between the development of
periventricular white matter lucency and autoregulation of cerebral blood flow in hypertensive …

Proton MR spectroscopic study at 3 Tesla on glutamate/glutamine in Alzheimer's disease

N Hattori, K Abe, S Sakoda, T Sawada - Neuroreport, 2002 - journals.lww.com
To investigate metabolic changes in Alzheimer's disease (AD), we performed proton MR
spectroscopy at 3 T. Spectra were acquired from the gray matter of the posterior cingulate gyrus …

Sarpogrelate-Aspirin Comparative Clinical Study for Efficacy and Safety in Secondary Prevention of Cerebral Infarction (S-ACCESS) A Randomized, Double-Blind …

Y Shinohara, K Nishimaru, T Sawada, A Terashi… - Stroke, 2008 - Am Heart Assoc
Background and Purpose— The antiplatelet agent sarpogrelate is a selective inhibitor of 5-hydroxytryptamine
receptors. The purpose of this study was to compare the efficacy and …