A large body of published work shows that proton (hydrogen 1 [ 1 H]) magnetic resonance (MR)
spectroscopy has evolved from a research tool into a clinical neuroimaging modality. …

Proton MRS ( 1 H MRS) provides noninvasive, quantitative metabolite profiles of tissue and
has been shown to aid the clinical management of several brain diseases. Although most …

Manganese (Mn), upon absorption, is primarily sequestered in tissue and intracellular
compartments. For this reason, blood Mn concentration does not always accurately reflect Mn …

Schizophrenia is a major psychiatric disease, which affects the centre of the personality,
with severe problems of perception, cognition as well as affective and social behaviour. In …

The human anterior cingulate cortex (ACC) is part of the default-mode network that shows
predominant negative blood oxygen level–dependent (BOLD) responses in functional …

… Drs Dydak and Boesiger supervised the MRS protocol optimization and validation and
revised the manuscript; Dr Boesiger also provided the magnetic resonance scanner. Dr Northoff …

… Then the unfolding matrix U is given by: … U is the unfolding matrix as defined in Eq. [1]
and the sinc-function, centered in the voxel x,y, is periodic according to the reduced FOV. …

Magnetic resonance spectroscopy (MRS) is the only biomedical imaging method that can
noninvasively detect endogenous signals from the neurotransmitter γ-aminobutyric acid (GABA…

Background Exposure to excessive levels of manganese (Mn) is known to induce psychiatric
and motor disorders, including parkinsonian symptoms. Therefore, finding a reliable means …

… Dydak and Zheng broaden the spectrum of neurotransmitters impaired by Mn exposure
and offers a potentially reliable new marker of Mn-associated early stage neuronal injury. …