Basic principles of immunological surveillance of the normal central nervous system
WF Hickey - Glia, 2001 - Wiley Online Library
Unlike most bodily organs, the central nervous system (CNS) exists behind a blood–tissue
barrier designed to minimize the passage of cells and macromolecules into the neural …
barrier designed to minimize the passage of cells and macromolecules into the neural …
[HTML][HTML] Leukocyte traffic in the central nervous system: the participants and their roles
WF Hickey - Seminars in immunology, 1999 - Elsevier
While the central nervous system has long been considered immunologically privileged, over
the past decade it has become evident that a wide variety of leukocyte types traffic through …
the past decade it has become evident that a wide variety of leukocyte types traffic through …
Migration of hematogenous cells through the blood‐brain barrier and the initiation of CNS inflammation
WF Hickey - Brain pathology, 1991 - Wiley Online Library
… and ultrastructural levels 'using rat bone marrow chimeras demonstrates conclusively that
the normal CNS contains a number of cell types derived from the bone marrow (Hickey, Vass …
the normal CNS contains a number of cell types derived from the bone marrow (Hickey, Vass …
T‐lymphocyte entry into the central nervous system
WF Hickey, BL Hsu, H Kimura - Journal of neuroscience …, 1991 - Wiley Online Library
The entry of T‐lymphocytes into the parenchyma of the central nervous system is a critical
early feature in the pathogenesis of many experimental and spontaneously occurring immune‐…
early feature in the pathogenesis of many experimental and spontaneously occurring immune‐…
Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo
WF Hickey, H Kimura - Science, 1988 - science.org
A crucial question in the study of immunological reactions in the central nervous system (CNS)
concerns the identity of the parenchymal cells that function as the antigen-presenting …
concerns the identity of the parenchymal cells that function as the antigen-presenting …
Normal adult ramified microglia separated from other central nervous system macrophages by flow cytometric sorting. Phenotypic differences defined and direct ex …
AL Ford, AL Goodsall, WF Hickey… - Journal of immunology …, 1995 - journals.aai.org
Ramified microglia in the adult central nervous system (CNS) are the principal glial element
up-regulating MHC class I and II expression in response to inflammatory events or neuronal …
up-regulating MHC class I and II expression in response to inflammatory events or neuronal …
bcl-2 protein expression is widespread in the developing nervous system and retained in the adult PNS
Cell death is a common feature of neural development in all vertebrates. The bcl-2 proto-oncogene
has been shown to protect a variety of cell types from programmed cell death. We …
has been shown to protect a variety of cell types from programmed cell death. We …
Bone marrow derived elements and resident microglia in brain inflammation
H Lassmann, M Schmied, K Vass, WF Hickey - Glia, 1993 - Wiley Online Library
… We have used the model of bone marrow radiation chimeras (Hickey and Kimura, 1988; …
F., Vass, K., and Hickey, WF t1991bi Microglial cells are a component of the perivascular …
F., Vass, K., and Hickey, WF t1991bi Microglial cells are a component of the perivascular …
Bone marrow-derived elements in the central nervous system: an immunohistochemical and ultrastructural survey of rat chimeras
WF Hickey, K Vass, H Lassmann - Journal of neuropathology …, 1992 - academic.oup.com
This report defines the bone marrow-derived elements found in the central nervous system
of adult rat radiation chimeras. Four cell types were identified which bore the major …
of adult rat radiation chimeras. Four cell types were identified which bore the major …
Dissociation of microglial activation and neuropathic pain behaviors following peripheral nerve injury in the rat
…, AJ Rickman, MP Yeager, P Kwon, WF Hickey - Journal of …, 1997 - Elsevier
Peripheral nerve injury commonly leads to neuropathic pain states fostered, in part, by
neuroimmunologic events. We used two models of neuropathic pain (L5 spinal nerve …
neuroimmunologic events. We used two models of neuropathic pain (L5 spinal nerve …