Basic principles of immunological surveillance of the normal central nervous system

WF Hickey - Glia, 2001 - Wiley Online Library
Unlike most bodily organs, the central nervous system (CNS) exists behind a blood–tissue
barrier designed to minimize the passage of cells and macromolecules into the neural …

[HTML][HTML] Leukocyte traffic in the central nervous system: the participants and their roles

WF Hickey - Seminars in immunology, 1999 - Elsevier
While the central nervous system has long been considered immunologically privileged, over
the past decade it has become evident that a wide variety of leukocyte types traffic through …

Migration of hematogenous cells through the blood‐brain barrier and the initiation of CNS inflammation

WF Hickey - Brain pathology, 1991 - Wiley Online Library
… and ultrastructural levels 'using rat bone marrow chimeras demonstrates conclusively that
the normal CNS contains a number of cell types derived from the bone marrow (Hickey, Vass …

T‐lymphocyte entry into the central nervous system

WF Hickey, BL Hsu, H Kimura - Journal of neuroscience …, 1991 - Wiley Online Library
The entry of T‐lymphocytes into the parenchyma of the central nervous system is a critical
early feature in the pathogenesis of many experimental and spontaneously occurring immune‐…

Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo

WF Hickey, H Kimura - Science, 1988 - science.org
A crucial question in the study of immunological reactions in the central nervous system (CNS)
concerns the identity of the parenchymal cells that function as the antigen-presenting …

Normal adult ramified microglia separated from other central nervous system macrophages by flow cytometric sorting. Phenotypic differences defined and direct ex …

AL Ford, AL Goodsall, WF Hickey… - Journal of immunology …, 1995 - journals.aai.org
Ramified microglia in the adult central nervous system (CNS) are the principal glial element
up-regulating MHC class I and II expression in response to inflammatory events or neuronal …

bcl-2 protein expression is widespread in the developing nervous system and retained in the adult PNS

DE Merry, DJ Veis, WF Hickey… - Development, 1994 - journals.biologists.com
Cell death is a common feature of neural development in all vertebrates. The bcl-2 proto-oncogene
has been shown to protect a variety of cell types from programmed cell death. We …

Bone marrow derived elements and resident microglia in brain inflammation

H Lassmann, M Schmied, K Vass, WF Hickey - Glia, 1993 - Wiley Online Library
… We have used the model of bone marrow radiation chimeras (Hickey and Kimura, 1988; …
F., Vass, K., and Hickey, WF t1991bi Microglial cells are a component of the perivascular …

Bone marrow-derived elements in the central nervous system: an immunohistochemical and ultrastructural survey of rat chimeras

WF Hickey, K Vass, H Lassmann - Journal of neuropathology …, 1992 - academic.oup.com
This report defines the bone marrow-derived elements found in the central nervous system
of adult rat radiation chimeras. Four cell types were identified which bore the major …

Dissociation of microglial activation and neuropathic pain behaviors following peripheral nerve injury in the rat

…, AJ Rickman, MP Yeager, P Kwon, WF Hickey - Journal of …, 1997 - Elsevier
Peripheral nerve injury commonly leads to neuropathic pain states fostered, in part, by
neuroimmunologic events. We used two models of neuropathic pain (L5 spinal nerve …