Muscular weakness and muscle wasting in the critically ill

…, JJ Grunow, MM Luedi, WJ Z'Graggen… - Journal of cachexia …, 2020 - Wiley Online Library
Background Muscular weakness and/or muscle wasting is recognized as a key medical
problem in critically ill patients on intensive care units (ICUs) worldwide. Methods and Results …

Dysfunction of respiratory muscles in critically ill patients on the intensive care unit

…, W Doehner, J Takala, WJ Z'Graggen… - Journal of cachexia …, 2016 - Wiley Online Library
Muscular weakness and muscle wasting may often be observed in critically ill patients on
intensive care units (ICUs) and may present as failure to wean from mechanical ventilation. …

Neurite growth inhibitors restrict plasticity and functional recovery following corticospinal tract lesions

M Thallmair, GAS Metz, WJ Z'Graggen… - Nature …, 1998 - nature.com
Anatomical plasticity and functional recovery after lesions of the rodent corticospinal tract (CST)
decrease postnatally in parallel with myelin formation. Myelin-associated neurite growth …

Functional recovery and enhanced corticofugal plasticity after unilateral pyramidal tract lesion and blockade of myelin-associated neurite growth inhibitors in adult rats

WJ Z'Graggen, GAS Metz, GL Kartje… - Journal of …, 1998 - Soc Neuroscience
After a lesion of the mature CNS, structural plasticity and functional recovery are very limited,
in contrast to the developing CNS. The postnatal decrease in plasticity is correlated in time …

Decompressive hemicraniectomy in patients with supratentorial intracerebral hemorrhage

C Fung, M Murek, WJ Z'Graggen, AK Krähenbühl… - Stroke, 2012 - Am Heart Assoc
Background and Purpose— Decompressive craniectomy (DC) lowers intracranial pressure
and improves outcome in patients with malignant middle cerebral artery stroke. Its usefulness …

Critical illness myopathy

WJ Z'Graggen, H Tankisi - Journal of Clinical Neurophysiology, 2020 - journals.lww.com
Critical illness myopathy (CIM) is a primary myopathy associated with increased mortality and
morbidity, which frequently develops in severely ill patients. Several risk factors have been …

Impact of coil position and electrophysiological monitoring on determination of motor thresholds to transcranial magnetic stimulation

AB Conforto, WJ Z'Graggen, AS Kohl, KM Rösler… - Clinical …, 2004 - Elsevier
Objective: We compared motor and movement thresholds to transcranial magnetic
stimulation (TMS) in healthy subjects and investigated the effect of different coil positions on …

Diskogenic microspurs as a major cause of intractable spontaneous intracranial hypotension

…, ML Mono, P Mordasini, E Hewer, WJ Z'Graggen… - Neurology, 2016 - AAN Enterprises
Objective: To visualize and treat spinal dural CSF leaks in all patients with intractable
spontaneous intracranial hypotension (SIH) who underwent spinal microsurgical exploration. …

Nerve excitability changes in critical illness polyneuropathy

WJ Z'Graggen, CSY Lin, RS Howard, RJ Beale… - Brain, 2006 - academic.oup.com
Patients in intensive care units frequently suffer muscle weakness and atrophy due to critical
illness polyneuropathy (CIP), an axonal neuropathy associated with systemic inflammatory …

Spinal cerebrospinal fluid leak as the cause of chronic subdural hematomas in nongeriatric patients

…, M Gosau, E Hattingen, K Gutbrod, WJ Z'Graggen… - Journal of …, 2014 - thejns.org
Object The etiology of chronic subdural hematoma (CSDH) in nongeriatric patients (≤ 60
years old) often remains unclear. The primary objective of this study was to identify spinal CSF …