Two-stage expression of neurofilament polypeptides during rat neurogenesis with early establishment of adult phosphorylation patterns

…, JQ Trojanowski, WW Schlaepfer… - Journal of …, 1987 - Soc Neuroscience
Monoclonal antibodies (mAbs) to rat neurofilament (NF) proteins NF-L, NF-M, and NF-H were
used to examine the developmental programs of NF expression in rat embryos. The ability …

Brain MR: pathologic correlation with gross and histopathology. 1. Lacunar infarction and Virchow-Robin spaces

…, WF Hickey, WW Schlaepfer - American Journal of …, 1988 - Am Roentgen Ray Soc
MR imaging was performed on 36 formalin-fixed brain specimens. For three of these specimens,
in vivo MR studies had also been performed before death. Changes that take place in …

Brain MR: pathologic correlation with gross and histopathology. 2. Hyperintense white-matter foci in the elderly

…, WF Hickey, WW Schlaepfer - American journal …, 1988 - Am Soc Neuroradiology
MR was performed on 23 formalin-fixed brain specimens of patients 60 years old or older at
the time of death. In two of these subjects MR had also been performed in vivo prior to death. …

PyK2 and FAK connections to p190Rho guanine nucleotide exchange factor regulate RhoA activity, focal adhesion formation, and cell motility

…, R Canete-Soler, J Zhai, H Lin, WW Schlaepfer… - The Journal of cell …, 2008 - rupress.org
Integrin binding to matrix proteins such as fibronectin (FN) leads to formation of focal adhesion
(FA) cellular contact sites that regulate migration. RhoA GTPases facilitate FA formation, …

Monoclonal antibodies distinguish several differentially phosphorylated states of the two largest rat neurofilament subunits (NF-H and NF-M) and demonstrate their …

VM Lee, MJ Carden, WW Schlaepfer… - Journal of …, 1987 - Soc Neuroscience
A new panel of greater than 300 monoclonal antibodies (mAbs) was prepared to the high,
middle, and low Mr rat neurofilament (NF) subunits (NF-H, NF-M and NF-L, respectively). NF …

[HTML][HTML] Direct interaction of focal adhesion kinase with p190RhoGEF

…, WW Schlaepfer, DD Schlaepfer - Journal of Biological …, 2003 - ASBMB
Focal adhesion kinase (FAK) is a protein-tyrosine kinase that associates with multiple cell
surface receptors and signaling proteins through which it can modulate the activity of several …

Disruption of neurofilament network with aggregation of light neurofilament protein: a common pathway leading to motor neuron degeneration due to Charcot–Marie …

…, H Lin, JP Julien, WW Schlaepfer - Human molecular …, 2007 - academic.oup.com
Mutations in neurofilament light (NFL) subunit and small heat-shock protein B1 (HSPB1)
cause autosomal-dominant axonal Charcot–Marie–Tooth disease type 2E (CMT2E) and type …

Characterization of the calcium-induced disruption of neurofilaments in rat peripheral nerve

WW Schlaepfer, MB Hasler - Brain research, 1979 - Elsevier
Transverse frozen sections of desheathed rat peripheral nerve were incubated in media of
different composition prior to fixation and processing for electron microscopic examination. …

Characterization of a brain calcium-activated protease that degrades neurofilament proteins

UJP Zimmerman, WW Schlaepfer - Biochemistry, 1982 - ACS Publications
Un-Jin P. Zimmerman** and William W. Schlaepfer abstract: A Ca2+-dependent protease was
prepared from rat brain by using DEAE-Sephadex, Sephadex G-200, and substrate affinity …

Structural alterations of peripheral nerve induced by the calcium ionophore A23187

WW Schlaepfer - Brain research, 1977 - Elsevier
Desheathed segments of rat peripheral nerve were incubated at 37C in oxygenated Ringer's
solution with and without the addition of calcium ionophore, A23187, 10 μg/ml. Nerve fibers …