[HTML][HTML] Racemization of Asp23 residue affects the aggregation properties of Alzheimer amyloid beta protein analogues.

T Tomiyama, S Asano, Y Furiya, T Shirasawa… - Journal of Biological …, 1994 - Elsevier
The beta proteins in amyloid deposits of Alzheimer's disease have been found to be racemized
and/or isomerized at their Asp residues (Roher, AE, Lowenson, JD, Clarke, S., Wolkow, C…

Amyloid β protein 42 (43) in cerebrospinal fluid of patients with Alzheimer's disease

…, E Matsubara, M Shoji, S Hirai, Y Furiya… - Journal of the …, 1997 - Elsevier
To investigate the pathomechanism of amyloid β protein (Aβ) deposition in brains with
Alzheimer's disease (AD), cerebrospinal fluid (CSF) levels of Aβ species (CSF-Aβ) with different …

Design of Chiral Bis-phosphoric Acid Catalyst Derived from (R)-3,3′-Di(2-hydroxy-3-arylphenyl)binaphthol: Catalytic Enantioselective Diels–Alder Reaction of α,β …

N Momiyama, T Konno, Y Furiya… - Journal of the …, 2011 - ACS Publications
Chiral bis-phosphoric acid 1 was designed to identify a new class of structural features in
chiral Brønsted acid catalysts. X-ray diffraction analysis revealed the single atropisomer 1, …

Characteristic neuroimaging in patients with tumefactive demyelinating lesions exceeding 30 mm

…, E Tanizawa, M Kawahara, Y Furiya… - Journal of …, 2011 - Wiley Online Library
BACKGROUND AND PURPOSE Features of tumefactive demyelinating lesion (TDL) on
magnetic resonance imaging (MRI) can facilitate the differential diagnosis of TDL and neoplastic …

ALADINI482S causes selective failure of nuclear protein import and hypersensitivity to oxidative stress in triple A syndrome

M Hirano, Y Furiya, H Asai, A Yasui… - Proceedings of the …, 2006 - National Acad Sciences
Triple A syndrome is an autosomal recessive neuroendocrinological disease caused by
mutations in a gene that encodes 546 amino acid residues. The encoded protein is the …

Tau in cerebrospinal fluids: establishment of the sandwich ELISA with antibody specific to the repeat sequence in tau

…, K Hosoda, E Matsubara, T Nakamoto, Y Furiya… - Neuroscience …, 1995 - Elsevier
… Correlation of two ELISAs PAb of anti-ht2 (x-axis) and MAb of F-F11 (y-axis) were used as
… seen (r = 0.967) except the slope of the regression li~e is 0.624 and the y intereept is 0.084. …

DNA single‐strand break repair is impaired in aprataxin‐related ataxia

…, M Aoki, K Shimada, Y Furiya… - Annals of Neurology …, 2007 - Wiley Online Library
Objective Early‐onset ataxia with ocular motor apraxia and hypoalbuminemia (EAOH)/ataxia
with oculomotor apraxia type 1 (AOA1) is an autosomal recessive form of cerebellar ataxia. …

Humanin detected in skeletal muscles of MELAS patients: a possible new therapeutic agent

S Kariya, M Hirano, Y Furiya, K Sugie, S Ueno - Acta neuropathologica, 2005 - Springer
Humanin (HN) was originally identified as an endogenous peptide that protects neuronal
cells from apoptosis induced by various types of Alzheimer’s disease-related insults. We have …

Cerebrospinal fluid-orexin levels and sleep attacks in four patients with Parkinson's disease

H Asai, M Hirano, Y Furiya, F Udaka… - Clinical Neurology and …, 2009 - Elsevier
OBJECTIVES: Sleep attacks (SAs) in Parkinson's disease (PD) are rare, but clinically important
because they significantly impair the daily lives of patients. Causes of SAs include long-…

Protein kinase Cγ, a protein causative for dominant ataxia, negatively regulates nuclear import of recessive-ataxia-related aprataxin

…, K Shimada, T Kiriyama, Y Furiya… - Human molecular …, 2009 - academic.oup.com
Spinocerebellar ataxia type 14 (SCA14) is an autosomal dominant disease caused by
mutations in the gene encoding protein kinase Cγ (PKCγ). We report an SCA14 family with a …