Background Unconscious survivors of out-of-hospital cardiac arrest have a high risk of death
or poor neurologic function. Therapeutic hypothermia is recommended by international …

<p id="p001">Life-threatening opioid intoxication developed in a patient after he was given
small doses of codeine for the treatment of a cough associated with bilateral pneumonia. …

… GF Hamann, Y. Okada & GJ Del Zoppo: Hemorrhagic transformation and microvascular
integrity during focal cerebral ischemi/reperfusion. J Cereb Blood Flow Metab 16(6), 1373-1378 (…

… Yvan Gasche … Y. Gasche is a research fellow supported by the Geneva University
Hospital Fund. PH Chan is a recipient of the Jacob Javits Neuroscience Investigator Award. …

Results of recent studies reveal vascular and neuroprotective effects of matrix metalloproteinase-9
(MMP-9) inhibition and MMP-9 gene deletion in experimental stroke. However, the …

Blood–brain barrier (BBB) disruption is thought to play a critical role in the pathophysiology
of ischemia/reperfusion. Matrix metalloproteinases (MMPs) are a family of proteolytic …

Oxidative stress generated during stroke is a critical event leading to blood–brain barrier (BBB)
disruption with secondary vasogenic edema and hemorrhagic transformation of infarcted …

Background : Neuron-specific enolase (NSE) is a widely-used biomarker for prognostication
of neurological outcome after cardiac arrest, but the relevance of recommended cutoff …

… Y. Gasche reports no disclosures. C. Hassager receives grant support from the Interreg IVA
ØKS program; honorarium for lectures from AstraZeneca, Teva, Novartis, and ViCare Medical…

Mitochondria are known to be involved in the early stage of apoptosis by releasing cytochrome
c, caspase-9, and the second mitochondria-derived activator of caspases (Smac). We …